10 Result(s)

Article

A computational method for prioritizing targeted therapies in precision oncology: performance analysis in the SHIVA01 trial

Precision oncology is currently based on pairing molecularly targeted agents (MTA) to predefined single driver genes or biomarkers. Each tumor harbors a combination of a large number of potential genetic alter...

Istvan Petak, Maud Kamal, Anna Dirner, Ivan Bieche, Robert Doczi… in npj Precision Oncology (2021)

Article

Exploring the landscape of focal amplifications in cancer using AmpliconArchitect

Focal oncogene amplification and rearrangements drive tumor growth and evolution in multiple cancer types. We present AmpliconArchitect (AA), a tool to reconstruct the fine structure of focally amplified regio...

Viraj Deshpande, Jens Luebeck, Nam-Phuong D. Nguyen… in Nature Communications (2019)

Article

Erratum to: Contribution of clinical and socioeconomic factors to differences in breast cancer subtype and mortality between Hispanic and non-Hispanic white women

María Elena Martínez, Scarlett L. Gomez, Li Tao… in Breast Cancer Research and Treatment (2017)

Article

MDR-1 and MRP-1 activity in peripheral blood leukocytes of rheumatoid arthritis patients

Rheumatoid Arthritis is a chronic disease leading to decreased quality of life with a rather variable response rate to Disease Modifying Anti Rheumatic Drugs. Methotrexate (MTX) is the gold standard therapy in...

Tamás Micsik, András Lőrincz, János Gál, Richard Schwab… in Diagnostic Pathology (2015)

Article

Decreased functional activity of multidrug resistance protein in primary colorectal cancer

The ATP-Binding Cassette (ABC)-transporter MultiDrug Resistance Protein 1 (MDR1) and Multidrug Resistance Related Protein 1 (MRP1) are expressed on the surface of enterocytes, which has led to the belief that ...

Tamás Micsik, András Lőrincz, Tamás Mersich, Zsolt Baranyai… in Diagnostic Pathology (2015)

Article

Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor

Gastrointestinal stromal tumor (GIST) is the most common sarcoma and its treatment with imatinib has served as the paradigm for develo** targeted anti-cancer therapies. Despite this success, imatinib-resista...

Jason K Sicklick, Stephanie Y Leonard… in Journal of Translational Medicine (2014)

Article

MutaScope: a high-sensitivity variant caller dedicated to high-throughput PCR amplicons sequencing

Shawn Yost, Hakan Alakus, Hiroko Matsui, Kristen Jepsen, Richard Schwab… in BMC Proceedings (2012)

Article

Malignant fibrous histiocytoma of the face: report of a case

Soft tissue sarcomas in the head and neck region are rare and often present a difficult differential diagnosis. The aim of our presentation is to point out the complexity of the diagnosis, treatment and follow...

László Seper, Richárd Schwab, Sirichai Kiattavorncharoen… in Head & Face Medicine (2007)

Article

TT-232: An Anti-tumour and Anti-inflammatory Peptide Therapeutic in Clinical Development

TT-232 is a structural derivative of the peptide hormone somatostatin with selective anti-proliferative and anti-inflammatory properties. It has a strong anti-tumour activity both in vitro and in vivo on a wide r...

György Kéri, Richard Schwab… in International Journal of Peptide Research … (2005)

Article

Identification of differentially regulated gene targets in the Myc and Mad family proteins

Ronan O'Hagan, Nicole Schreiber-Agus, Jeffrey A. Engelman… in Nature Genetics (1999)