3 Result(s)

Article

A computational method for prioritizing targeted therapies in precision oncology: performance analysis in the SHIVA01 trial

Precision oncology is currently based on pairing molecularly targeted agents (MTA) to predefined single driver genes or biomarkers. Each tumor harbors a combination of a large number of potential genetic alter...

Istvan Petak, Maud Kamal, Anna Dirner, Ivan Bieche, Robert Doczi… in npj Precision Oncology (2021)

Article

Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor

Gastrointestinal stromal tumor (GIST) is the most common sarcoma and its treatment with imatinib has served as the paradigm for develo** targeted anti-cancer therapies. Despite this success, imatinib-resista...

Jason K Sicklick, Stephanie Y Leonard… in Journal of Translational Medicine (2014)

Article

MutaScope: a high-sensitivity variant caller dedicated to high-throughput PCR amplicons sequencing

Shawn Yost, Hakan Alakus, Hiroko Matsui, Kristen Jepsen, Richard Schwab… in BMC Proceedings (2012)