1,496 Result(s)

Article

Synthetic macrolides overcoming MLS_BK-resistant pathogens

Conventional macrolide-lincosamide-streptogramin B-ketolide (MLS_BK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...

Cong-Xuan Ma, Ye Li, Wen-Tian Liu, Yun Li, Fei Zhao, **ao-Tian Lian… in Cell Discovery (2024)

Article

Publisher Correction: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice

Hong Xue, Zhenhua Feng, Putao Yuan, Li Qiao, Qiliang Lou… in Cell Death Discovery (2024)

Article

Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer

Cisplatin resistance is a major challenge for systemic therapy against advanced bladder cancer (BC). Little information is available on the regulation of cisplatin resistance and the underlying mechanisms requ...

Gaowei Huang, **wen Liu, Anze Yu, Chenggong Luo… in Cellular and Molecular Life Sciences (2024)

Article

Short-chain fatty acids suppresses astrocyte activation by amplifying Trp-AhR-AQP4 signaling in experimental autoimmune encephalomyelitis mice

The function of astrocytes in response to gut microbiota-derived signals has an important role in the pathophysiological processes of central nervous system (CNS) diseases. However, the specific effects of mic...

**uli Lin, Yufeng Peng, Zhimei Guo, Wuhui He… in Cellular and Molecular Life Sciences (2024)

Article

Origin recognition complex 6 overexpression promotes growth of glioma cells

The discovery of novel oncotargets for glioma is of immense significance. We here explored the expression patterns, biological functions, and underlying mechanisms associated with ORC6 (origin recognition comp...

Wen-lei Yang, Wei-feng Zhang, Yin Wang, Yue Lou, Yu Cai, Jun Zhu in Cell Death & Disease (2024)

Article

Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity

Aging and obesity pose significant threats to public health and are major contributors to muscle atrophy. The trends in muscle fiber types under these conditions and the transcriptional differences between dif...

Feng-Min Zhang, Hao-Fan Wu, Ke-Fan Wang, Ding-Ye Yu… in Cell Death & Disease (2024)

Article

A pan-KRAS degrader for the treatment of KRAS-mutant cancers

KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer progression and conferring resistance to treatment. While there have bee...

Jie Yang, Qiao-Li Wang, Guan-Nan Wang, Jia-Cong Ye, Zi-Qian Li… in Cell Discovery (2024)

Article

Aging and homeostasis of the hypodermis in the age-related deterioration of skin function

Adipose tissues in the hypodermis, the crucial stem cell reservoir in the skin and the endocrine organ for the maintenance of skin homeostasis undergo significant changes during skin aging. Dermal white adipos...

Meiqi Liu, Feng Lu, **gwei Feng in Cell Death & Disease (2024)

Article

CCL11 released by GSDMD-mediated macrophage pyroptosis regulates angiogenesis after hindlimb ischemia

Peripheral vascular disease (PVD) is an emerging public health burden with a high rate of disability and mortality. Gasdermin D (GSDMD) has been reported to exert pyroptosis and play a critical role in the pat...

Yiwen Wang, Yang Gao, Huairui Shi, Rifeng Gao, Ji’e Yang, Ya’nan Qu… in Cell Death Discovery (2024)

Article

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...

Mengqi Li, Yu Wang, **aoyan Wei, Wei-Feng Cai, Jianfeng Wu, Mingxia Zhu… in Cell Research (2024)

Article

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity

Natural killer (NK) cells play a crucial role in immune response against viral infections and tumors. However, further investigation is needed to better understand the key molecules responsible for determining...

Peiran Feng, Liang Luo, Quanli Yang, Wanqing Meng, Zerong Guan… in Cell Death & Disease (2024)

Article

TMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling

Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly ...

Chen Zhang, Fang Tong, Bin Zhou, Mingdong He, Shuai Liu, **aomeng Zhou… in Cell Discovery (2024)

Article

Synergistic immunochemotherapy targeted SAMD4B-APOA2-PD-L1 axis potentiates antitumor immunity in hepatocellular carcinoma

Targeted and immunotherapy combined with interventional therapy can improve the prognosis of advanced cancer patients, and it has become a hot spot to find the new therapeutic schemes, but most of which are no...

Feng Qi, Jian Zhang, Jia Li, Donghe Li, Na Gao, Zhuoran Qi… in Cell Death & Disease (2024)

Article

EEF1B2 regulates bone marrow-derived mesenchymal stem cells bone-fat balance via Wnt/β-catenin signaling

The pathological advancement of osteoporosis is caused by the uneven development of bone marrow-derived mesenchymal stem cells (BMSCs) in terms of osteogenesis and adipogenesis. While the role of EEF1B2 in int...

Shuhao Feng, Zihang Feng, Yiran Wei, **aoyong Zheng… in Cellular and Molecular Life Sciences (2024)

Article

EHHADH deficiency regulates pexophagy and accelerates tubulointerstitial injury in diabetic kidney disease

Peroxisomal l-bifunctional enzyme (EHHADH) plays a role in the classic peroxisomal fatty acid β-oxidation pathway; however, the relationship between EHHADH expression and diabetic kidney disease has not been well...

Shuyan Kan, Qing Hou, **song Shi, Mingchao Zhang, Feng Xu… in Cell Death Discovery (2024)

Article

Evolutionary Game Dynamics with Environmental Feedback in a Network with Two Communities

Recent developments of eco-evolutionary models have shown that evolving feedbacks between behavioral strategies and the environment of game interactions, leading to changes in the underlying payoff matrix, can...

Katherine Betz, Feng Fu, Naoki Masuda in Bulletin of Mathematical Biology (2024)

Article

Gasdermin D silencing alleviates airway inflammation and remodeling in an ovalbumin-induced asthmatic mouse model

Emerging evidence demonstrates that pyroptosis has been implicated in the pathogenesis of asthma. Gasdermin D (GSDMD) is the pyroptosis executioner. The mechanism of GSDMD in asthma remains unclear. The aim of...

**xiang Wu, Pin Wang, **nyu **e, **aoqi Yang, Shuangmei Tang… in Cell Death & Disease (2024)