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  1. Article

    Open Access

    Histone H1.0 couples cellular mechanical behaviors to chromatin structure

    Tuning of genome structure and function is accomplished by chromatin-binding proteins, which determine the transcriptome and phenotype of the cell. Here we investigate how communication between extracellular s...

    Shuaishuai Hu, Douglas J. Chapski, Natalie D. Gehred in Nature Cardiovascular Research (2024)

  2. Article

    Open Access

    Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair

    This study sought to develop an automated segmentation approach based on histogram analysis of raw axial images acquired by light-sheet fluorescent imaging (LSFI) to establish rapid reconstruction of the 3-D z...

    René R. Sevag Packard, Kyung In Baek, Tyler Beebe, Nelson Jen in Scientific Reports (2017)

  3. Article

    Open Access

    Inductively powered wireless pacing via a miniature pacemaker and remote stimulation control system

    Pacemakers have existed for decades as a means to restore cardiac electrical rhythms. However, lead-related complications have remained a clinical challenge. While market-released leadless devices have address...

    Parinaz Abiri, Ahmad Abiri, René R. Sevag Packard, Yichen Ding in Scientific Reports (2017)

  4. Article

    Open Access

    Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function

    Light Sheet Fluorescence Microscopy (LSFM) enables multi-dimensional and multi-scale imaging via illuminating specimens with a separate thin sheet of laser. It allows rapid plane illumination for reduced photo...

    Peng Fei, Juhyun Lee, René R. Sevag Packard in Scientific Reports (2016)