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Open AccessBiodiversity losses associated with global warming of 1.5 to 4 °C above pre-industrial levels in six countries
We quantify the projected impacts of alternative levels of global warming upon the climatically determined geographic ranges of plants and vertebrates in six countries (China, Brazil, Egypt, Ethiopia, Ghana an...
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Article
Open AccessRisks associated with global warming of 1.5 to 4 °C above pre-industrial levels in human and natural systems in six countries
The Topical Collection “Accrual of Climate Change Risk in Six Vulnerable Countries” provides a harmonised assessment of risks to human and natural systems due to global warming of 1.5–4 °C in six countries (Ch...
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Open AccessGlobal and regional aggregate damages associated with global warming of 1.5 to 4 °C above pre-industrial levels
We quantify global and regional aggregate damages from global warming of 1.5 to 4 °C above pre-industrial levels using a well-established integrated assessment model, PAGE09. We find mean global aggregate damages...
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Open AccessProspective evaluation of the cardiac safety of HER2-targeted therapies in patients with HER2-positive breast cancer and compromised heart function: the SAFE-HEaRt study
HER2-targeted therapies have substantially improved the outcome of patients with breast cancer, however, they can be associated with cardiac toxicity. Guidelines recommend holding HER2-targeted therapies until...
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Open AccessThe implications of the United Nations Paris Agreement on climate change for globally significant biodiversity areas
Climate change is already affecting species and their distributions. Distributional range changes have occurred and are projected to intensify for many widespread plants and animals, creating associated risks ...
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Article
Interpretation of thyroid scintigraphy is inconsistent among endocrinologists
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Open AccessSurvival and re-aerosolization in dust of Mycobacterium smegmatis, a surrogate marker for Mycobacterium tuberculosis
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Article
The AVOID programme’s new simulations of the global benefits of stringent climate change mitigation
Quantitative simulations of the global-scale benefits of climate change mitigation are presented, using a harmonised, self-consistent approach based on a single set of climate change scenarios. The approach dr...
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Quantifying the benefit of early climate change mitigation in avoiding biodiversity loss
Climate change is expected to significantly influence biodiversity, but the performance of climate change mitigation strategies in reducing these impacts is not yet known. Simulations of the future ranges of c...
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Variation in the climatic response to SRES emissions scenarios in integrated assessment models
Integrated assessment models (IAMs) have commonly been used to understand the relationship between the economy, the earth’s climate system and climate impacts. We compare the IPCC simulations of CO2 concentration...
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Article
Open AccessBreast cancer risk factors and a novel measure of volumetric breast density: cross-sectional study
We conducted a cross-sectional study nested within a prospective cohort of breast cancer risk factors and two novel measures of breast density volume among 590 women who had attended Glasgow University (1948–1...
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Open AccessCost-effectiveness of screening with contrast enhanced magnetic resonance imaging vs X-ray mammography of women at a high familial risk of breast cancer
Contrast enhanced magnetic resonance imaging (CE MRI) is the most sensitive tool for screening women who are at high familial risk of breast cancer. Our aim in this study was to assess the cost-effectiveness o...
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Update on magnetic resonance screening and the MARIBS trial
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Article
Biological activities of a recombinant adenovirus p53 (SCH 58500) administered by hepatic arterial infusion in a Phase 1 colorectal cancer trial
The major focus of intrahepatic arterial (IHA) administration of adenoviruses (Ad) has been on safety. Currently, there is little published data on the biological responses to Ad when administered via this rou...
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Article
An Integrated Assessment Model for Fine Particulate Matter in Europe
Exposure to fine particles in the ambient air is recognized as a significant threat to human health. Two pathways contribute to the particle burden in the atmosphere: Fine particles originate from primary emis...
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Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial
Novel therapies are needed for locally advanced pancreatic carcinoma. ONYX-015 (dl1520) is an E1B-55 kDa region-deleted adenovirus that selectively replicates in and lyses tumor cells with abnormalities in p53...
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Article
Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy
Thymidylate synthase (TS) catalyses the conversion of deoxy-uridylate to deoxy-thymidylate and is essential for DNA synthesis. The human TS gene promoter is polymorphic, having either double or triple tandem r...
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Breast ultrasound in a "moderate risk" population
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Open AccessHigh risk mammographic parenchymal patterns and diet: a case–control study
Mammographic parenchymal patterns are related to breast cancer risk and are also thought to be affected by diet. We designed a case–control study comprising 200 cases with high-risk (P2 and DY) mammographic pa...
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Size, node status and grade of breast tumours: association with mammographic parenchymal patterns
A case-control study was designed to assess the association of mammographic parenchymal patterns with the risk of in-situ and invasive breast cancer. In addition, the relationship between tumour characteristi...
