5 Result(s)
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Article
R. Scott Hawley
Cell Biology
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Article
Open AccessGenetic background impacts the timing of synaptonemal complex breakdown in Drosophila melanogaster
Experiments performed in different genetic backgrounds occasionally exhibit failure in experimental reproducibility. This is a serious issue in Drosophila where there are no standard control stocks. Here, we illu...
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Homologue pairing: getting it right
In Caernorhabditis elegans, homologue pairing is mediated by specialized regions near one end of each chromosome in conjunction with zinc finger (ZnF)-bearing proteins. Families of repeated sequences that are enr...
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The spindle-associated transmembrane protein Axs identifies a membranous structure ensheathing the meiotic spindle
Mutations in the aberrant X segragation (Axs) gene disrupt the segregation of achiasmate chromosomes during female meiosis in Drosophila melanogaster. We show that Axs encodes the founding member of an eukaryotic...
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Hanging on to your homolog: the roles of pairing, synapsis and recombination in the maintenance of homolog adhesion
Homologous chromosomes initially undergo weak alignments that bring homologous sequences into register during meiosis. These alignments can be facilitated by two types of mechanisms: interstitial homology sear...
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mei-41 is required for precocious anaphase in Drosophila females
This paper reports on a new role for mei-41 in cell cycle control during meiosis. This function is revealed by the requirement of mei-41 for the precocious anaphase observed in crossover-defective mutants. Normal...
