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  1. Article

    Open Access

    A specific super-enhancer actuated by berberine regulates EGFR-mediated RAS–RAF1–MEK1/2–ERK1/2 pathway to induce nasopharyngeal carcinoma autophagy

    Nasopharyngeal carcinoma (NPC), primarily found in the southern region of China, is a malignant tumor known for its highly metastatic characteristics. The high mortality rates caused by the distant metastasis ...

    Yao Wu, Qunying Jia, Qi Tang, Lin Chen, Hongyu Deng in Cellular & Molecular Biology Letters (2024)

  2. Article

    Open Access

    JUN-induced super-enhancer RNA forms R-loop to promote nasopharyngeal carcinoma metastasis

    Oncogenic super-enhancers (SEs) generate noncoding enhancer/SE RNAs (eRNAs/seRNAs) that exert a critical function in malignancy through powerful regulation of target gene expression. Herein, we show that a JUN...

    Qunying Jia, Yuan Tan, Yue** Li, Yao Wu, **g Wang, Faqin Tang in Cell Death & Disease (2023)

  3. Article

    Open Access

    A novel oncogenic seRNA promotes nasopharyngeal carcinoma metastasis

    Nasopharyngeal carcinoma (NPC) is a common malignant cancer in southern China that has highly invasive and metastatic features and causes high mortality, but the underlying mechanisms of this malignancy remain...

    Yuan Tan, Chonghua Jiang, Qunying Jia, **g Wang, Ge Huang in Cell Death & Disease (2022)