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  1. Article

    Open Access

    Mechanistic target of rapamycin complex 1 orchestrates the interplay between hepatocytes and Kupffer cells to determine the outcome of immune-mediated hepatitis

    The cell-cell interaction between hepatocytes and Kupffer cells (KCs) is crucial for maintaining liver homeostasis, and the loss of KCs and hepatocytes is known to represent a common pathogenic phenomenon in a...

    **aoli Sun, Yajie Ni, Qingmiao Lu, Yan Liang, Mengru Gu, **an Xue… in Cell Death & Disease (2022)

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  2. Article

    Open Access

    PP2Acα promotes macrophage accumulation and activation to exacerbate tubular cell death and kidney fibrosis through activating Rap1 and TNFα production

    Macrophage accumulation and activation play an essential role in kidney fibrosis; however, the underlying mechanisms remain to be explored. By analyzing the kidney tissues from patients and animal models with ...

    Yan Liang, **aoli Sun, Mingjie Wang, Qingmiao Lu, Mengru Gu… in Cell Death & Differentiation (2021)

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  3. Article

    Open Access

    Loss of Rictor in tubular cells exaggerates lipopolysaccharide induced renal inflammation and acute kidney injury via Yap/Taz-NF-κB axis

    Our previous study demonstrated that the mammalian target of rapamycin complex 2 (mTORC2) signaling alleviates renal inflammation and protects against cisplatin-induced AKI. However, the underlying mechanisms ...

    Yuan Gui, Qing Hou, Qingmiao Lu, Chunsun Dai, Jianzhong Li in Cell Death Discovery (2020)

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  4. Article

    Open Access

    Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis

    Ras homolog enriched in brain (Rheb1), a small GTPase, plays a crucial role in regulating cell growth, differentiation, and survival. However, the role and mechanisms for Rheb1 in tubular cell survival and acu...

    Qingmiao Lu, Mingjie Wang, Yuan Gui, Qing Hou, Mengru Gu, Yan Liang… in Cell Death & Disease (2020)

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  5. No Access

    Article

    Fibroblast mTOR/PPARγ/HGF axis protects against tubular cell death and acute kidney injury

    Kidney fibroblasts play a crucial role in dictating tubular cell fate and the outcome of acute kidney injury (AKI). The underlying mechanisms remain to be determined. Here, we found that mTOR signaling was act...

    Yuan Gui, Qingmiao Lu, Mengru Gu, Mingjie Wang, Yan Liang… in Cell Death & Differentiation (2019)