16 Result(s)
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Article
Qinglian Li
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Article
Semi-synthesis and structure-activity relationship study yield antibacterial vicenistatin derivatives with low cytotoxicity
Vicenistatin (1) is a 20-membered polyketide macrocyclic antibiotic with potent antimicrobial and cytotoxic activities. In this study, to further explore the potential of 1 as candidates of antibacterial drug dev...
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Open AccessMoxibustion treatment for Parkinson’s disease: study protocol for a randomized controlled trial
Parkinson’s disease (PD) is the second most common neurodegenerative disorder and seriously affects quality of life globally. Moxibustion is widely used to treat neurodegenerative diseases in the clinic and ha...
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Open AccessUpregulation of a marine fungal biosynthetic gene cluster by an endobacterial symbiont
Fungal-bacterial associations are present in nature, playing important roles in ecological, evolutionary and medicinal processes. Here we report a fungus-bacterial symbiont from marine sediment. The bacterium ...
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The roles of genes associated with regulation, transportation, and macrocyclization in desotamide biosynthesis in Streptomyces scopuliridis SCSIO ZJ46
The deep-sea-derived microbe Streptomyces scopuliridis SCSIO ZJ46 produces desotamides A–D. Notably, desotamides A and B display antibacterial activities against pathogenic Gram-positive Streptococcus pneumoniae ...
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A nanocomposite prepared from hemin and reduced graphene oxide foam for voltammetric sensing of hydrogen peroxide
A foam consisting of reduced graphene oxide was synthesized by a one-pot hydrothermal method. The foam was used to prepare a nanocomposite with hemin which is formed via π-interactions. The nanocomposite was i...
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Open AccessCytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs in Streptomyces
Antibiotic-producing microorganism can develop strategies to deal with self-toxicity. Cytorhodins X and Y, cosmomycins A and B, and iremycin, are produced as final products from a marine-derived Streptomyces sp. ...
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Open AccessHopf bifurcation analysis for a model of plant virus propagation with two delays
In this paper, we consider a model of plant virus propagation with two delays and Holling type II functional response. The stability of the positive equilibrium and the existence of Hopf bifurcation are analyz...
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Fabrication of Tip-Dissolving Microneedles for Transdermal Drug Delivery of Meloxicam
Dissolving microneedles (MNs) offered a simple, minimally invasive method for meloxicam (MX) delivery to the skin. However, the fabrication of dissolving MNs still faced some challenges, such as significant ti...
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Open AccessCharacterization and heterologous expression of the neoabyssomicin/abyssomicin biosynthetic gene cluster from Streptomyces koyangensis SCSIO 5802
The deep-sea-derived microbe Streptomyces koyangensis SCSIO 5802 produces neoabyssomicins A–B (1–2) and abyssomicins 2 (3) and 4 (4). Neoabyssomicin A (1) augments human immunodeficiency virus-1 (HIV-1) replicati...
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Open AccessIdentification and utilization of two important transporters: SgvT1 and SgvT2, for griseoviridin and viridogrisein biosynthesis in Streptomyces griseoviridis
Griseoviridin (GV) and viridogrisein (VG, also referred as etamycin), both biosynthesized by a distinct 105 kb biosynthetic gene cluster (BGC) in Streptomyces griseoviridis NRRL 2427, are a pair of synergistic st...
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Open AccessStability and Hopf bifurcation of a modified predator-prey model with a time delay and square root response function
In this paper, we consider a two-dimensional predator-prey model with a time delay and square root response function. We analyze the stability of equilibria with the delay τ increasing and the critical value of τ
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Open AccessA Magnetically Recoverable Fe3O4–NH2–Pd Sorbent for Capture of Mercury from Coal Derived Fuel Gas
A sort of magnetical material named Fe3O4–NH2–Pd was prepared by loading varying amounts of immobilizing Pd on the surface of the magnetic Fe3O4–NH2 microspheres. This magnetical material was used firstly for cap...
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Open AccessSingle-block pulse-on electro-optic Q-switch made of LiNbO 3
A novel LiNbO3 (lithium niobate, LN) electro-optic (EO) Q-switch that can independently operate in the pulse-on regime without the assistance of a quarter-wave plate (QWP) or analyzer was designed and demonstrate...
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An image-processing based method for the measurement of the film thickness of a swirl atomizer
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Study on transient structure characteristics of round liquid jet in supersonic crossflows
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Open AccessImproving the N-terminal diversity of sansanmycin through mutasynthesis
Sansanmycins are uridyl peptide antibiotics (UPAs), which are inhibitors of translocase I (MraY) and block the bacterial cell wall biosynthesis. They have good antibacterial activity against Pseudomonas aeruginos...
