644 Result(s)
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Article
Photothermal properties of Cu@polycarbonate composites with strong localized surface plasmon resonances
Copper is relatively low cost and highly abundant compared with the well-studied noble metals such as gold and silver. However, the poor plasmonic and high susceptibility towards oxidation limit the study of i...
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Open AccessHypermethylated TAGMe as a universal-cancer-only methylation marker and its application in diagnosis and recurrence monitoring of urothelial carcinoma
Urothelial carcinoma (UC) is the second most common urological malignancy. Despite numerous molecular markers have been evaluated during the past decades, no urothelial markers for diagnosis and recurrence mon...
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Enhancing osteogenic bioactivities of coaxial electrospinning nano-scaffolds through incorporating iron oxide nanoparticles and icaritin for bone regeneration
Bone tissue engineering provides a promising strategy for the treatment of bone defects. Nonetheless, the clinical utilization of biomaterial-based scaffolds is constrained by their inadequate mechanical stren...
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Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission
Status epilepticus (SE), a serious and often life-threatening medical emergency, is characterized by abnormally prolonged seizures. It is not effectively managed by present first-line anti-seizure medications ...
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Triggering triplet excitons of carbon nanodots through nanospace domain confinement for multicolor phosphorescence in aqueous solution
Easy non-radiative decay property of long-lived triplet excitons in aqueous solution obstructs their applications in aquatic surroundings. Recently reported phosphorescence phenomena in aqueous solution have e...
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Iron oxide/CNT-based artificial nacre for electromagnetic interference shielding
Biological structural materials, despite consisting of limited kinds of compounds, display multifunctionalities due to their complex hierarchical architectures. While some biomimetic strategies have been appli...
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Article
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway
Parkin (PARK2) deficiency is frequently observed in various cancers and potentially promotes tumor progression. Here, we showed that Parkin expression is downregulated in liver cancer tissues, which correlates wi...
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Open AccessNociceptor-immune interactomes reveal insult-specific immune signatures of pain
Inflammatory pain results from the heightened sensitivity and reduced threshold of nociceptor sensory neurons due to exposure to inflammatory mediators. However, the cellular and transcriptional diversity of i...
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MiR-214 promotes the antitumor effect of NK cells in colorectal cancer liver metastasis through USP27X/Bim
Colorectal cancer (CRC) is a common tumor type, and liver metastasis reduces the long-term survival in CRC patients. Natural killer (NK) cells play an important role in anti-tumor immunity. The aim of this stu...
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Open AccessEffect of ultrasound-guided injection of botulinum toxin type A into shoulder joint cavity on shoulder pain in poststroke patients: study protocol for a randomized controlled trial
Hemiplegic shoulder pain (HSP) is a common complication after stroke. It severely affects the recovery of upper limb motor function. Early shoulder pain in hemiplegic patients is mainly neuropathic caused by c...
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Open AccessDisrupting Smad3 potentiates immunostimulatory function of NK cells against lung carcinoma by promoting GM-CSF production
Through Smad3-dependent signalings, transforming growth factor-β (TGF-β) suppresses the development, maturation, cytokine productions and cytolytic functions of NK cells in cancer. Silencing Smad3 remarkably r...
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Depleting profibrotic macrophages using bioactivated in vivo assembly peptides ameliorates kidney fibrosis
Managing renal fibrosis is challenging owing to the complex cell signaling redundancy in diseased kidneys. Renal fibrosis involves an immune response dominated by macrophages, which activates myofibroblasts in...
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An efficient memory reserving-and-fading strategy for vector quantization based 3D brain segmentation and tumor extraction using an unsupervised deep learning network
Deep learning networks are state-of-the-art approaches for 3D brain image segmentation, and the radiological characteristics extracted from tumors are of great significance for clinical diagnosis, treatment pl...
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Article
PABPC1 silencing inhibits pancreatic cancer cell proliferation and EMT, and induces apoptosis via PI3K/AKT pathway
Pancreatic cancer is difficult to manage owing to the challenges involved in its treatment and nursing. This study aimed to clarify the roles and mechanisms of action of Poly (A)-binding protein cytoplasmic 1 ...
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Culture of cerebrospinal fluid-contacting neurons from neonatal mouse spinal cord
Cerebrospinal fluid-contacting neurons (CSF-cNs) act crucial role in chemosensory and mechanosensory function in spinal cord. Recently, CSF-cNs were found to be an immature neuron and may be involved in spinal...
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Open AccessHBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis
The root of Aconitum carmichaelii Debx. (Fuzi) is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases. A key toxic compound in Fuzi, aconitine (AC), could t...
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Assessment of impaired consciousness using EEG-based connectivity features and convolutional neural networks
Growing electroencephalogram (EEG) studies have linked the abnormities of functional brain networks with disorders of consciousness (DOC). However, due to network data’s high-dimensional and non-Euclidean prop...
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Open AccessDevelopment and validation of a preoperative CT‑based radiomics nomogram to differentiate tuberculosis granulomas from lung adenocarcinomas: an external validation study
An accurate and non-invasive approach is urgently needed to distinguish tuberculosis granulomas from lung adenocarcinomas. This study aimed to develop and validate a nomogram based on contrast enhanced-compute...
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Human amniotic epithelial stem cell is a cell therapy candidate for preventing acute graft-versus-host disease
Graft-versus-host disease (GVHD), an immunological disorder that arises from donor T cell activation through recognition of host alloantigens, is the major limitation in the application of allogeneic hematopoi...
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Open AccessRole of umbilical cord mesenchymal stromal cells in skin rejuvenation
Aging is the main cause of many degenerative diseases. The skin is the largest and the most intuitive organ that reflects the aging of the body. Under the interaction of endogenous and exogenous factors, there...
