841 Result(s)
-
Article
Open AccessSilicon photocathode functionalized with osmium complex catalyst for selective catalytic conversion of CO2 to methane
Solar-driven CO2 reduction to yield high-value chemicals presents an appealing avenue for combating climate change, yet achieving selective production of specific products remains a significant challenge. We show...
-
Article
Open AccessEfficient molecular do** of polymeric semiconductors improved by coupled reaction
Exploring chemical do** method to improve the electrical conductivity of polymers is still very attractive for researchers. In this work, we report a developed method of do** a polymer semiconductor aided ...
-
Article
Open AccessLeukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis
Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled proliferation of plasma cells in the bone marrow. MM patients with aggressive progression have poor survival, emphasizing the urg...
-
Article
Open AccessMetal-ligand dual-site single-atom nanozyme mimicking urate oxidase with high substrates specificity
In nature, coenzyme-independent oxidases have evolved in selective catalysis using isolated substrate-binding pockets. Single-atom nanozymes (SAzymes), an emerging type of non-protein artificial enzymes, are p...
-
Article
Open AccessEngineered cytosine base editor enabling broad-scope and high-fidelity gene editing in Streptomyces
Base editing (BE) faces protospacer adjacent motif (PAM) constraints and off-target effects in both eukaryotes and prokaryotes. For Streptomyces, renowned as one of the most prolific bacterial producers of antibi...
-
Article
Open AccessCharacteristics of deformation and damage of surrounding rock along the top roadway in the working face of an isolated island and its evolution law
This study investigates the deformation and damage characteristics of the surrounding rock along the top return mining roadway of an isolated island working face at different stages and reveals its damage mech...
-
Article
Open AccessTamm-cavity terahertz detector
Efficiently fabricating a cavity that can achieve strong interactions between terahertz waves and matter would allow researchers to exploit the intrinsic properties due to the long wavelength in the terahertz ...
-
Article
Open AccessMyricetin mitigates motor disturbance and decreases neuronal ferroptosis in a rat model of Parkinson’s disease
Ferroptosis is an iron-dependent cell death form characterized by reactive oxygen species (ROS) overgeneration and lipid peroxidation. Myricetin, a flavonoid that exists in numerous plants, exhibits potent ant...
-
Article
Open AccessMicroscale geometrical modulation of PIEZO1 mediated mechanosensing through cytoskeletal redistribution
The microgeometry of the cellular microenvironment profoundly impacts cellular behaviors, yet the link between it and the ubiquitously expressed mechanosensitive ion channel PIEZO1 remains unclear. Herein, we ...
-
Article
Open AccessThe impact of telomere length on the risk of idiopathic normal pressure hydrocephalus: a bidirectional Mendelian randomization study
Idiopathic normal pressure hydrocephalus (iNPH) affects mainly aged populations. The gradual shortening of telomere length (TL) is one of the hallmarks of aging. Whereas the genetic contribution of TL to the i...
-
Article
Open AccessIdentification of bladder cancer subtypes and predictive signature for prognosis, immune features, and immunotherapy based on immune checkpoint genes
Immunotherapy based on immune checkpoint genes (ICGs) has recently made significant progress in the treatment of bladder cancer patients, but many patients still cannot benefit from it. In the present study, w...
-
Article
Open AccessPJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma
Chemoresistance is a main reason for treatment failure in patients with nasopharyngeal carcinoma, but the exact regulatory mechanism underlying chemoresistance in nasopharyngeal carcinoma remains to be elucida...
-
Article
Open AccessAtomic scale disorder and reconstruction in bulk infinite-layer nickelates lacking superconductivity
The recent discovery of superconductivity in infinite-layer nickelate films has sparked significant interest and expanded the realm of superconductors, in which the infinite-layer structure and proper chemical...
-
Article
Open AccessNatural variation in BnaA07.MKK9 confers resistance to Sclerotinia stem rot in oilseed rape
Sclerotinia stem rot (SSR), caused by the necrotrophic fungus Sclerotinia sclerotiorum, is one of the most devastating diseases for several major oil-producing crops. Despite its impact, the genetic basis of SSR ...
-
Article
Open AccessDesign of a water-soluble transmembrane receptor kinase with intact molecular function by QTY code
Membrane proteins are critical to biological processes and central to life sciences and modern medicine. However, membrane proteins are notoriously challenging to study, mainly owing to difficulties dictated b...
-
Article
Open AccessA haplotype-resolved genome assembly of Malus domestica ‘Red Fuji’
The ‘Red Fuji’ apple (Malus domestica), is one of the most important and popular economic crops worldwide in the fruit industry. Using PacBio HiFi long reads and Hi-C reads, we assembled a high-quality haplotype-...
-
Article
Open AccessIn-situ observation of silk nanofibril assembly via graphene plasmonic infrared sensor
Silk nanofibrils (SNFs), the fundamental building blocks of silk fibers, endow them with exceptional properties. However, the intricate mechanism governing SNF assembly, a process involving both protein confor...
-
Article
Open AccessChineseEEG: A Chinese Linguistic Corpora EEG Dataset for Semantic Alignment and Neural Decoding
An Electroencephalography (EEG) dataset utilizing rich text stimuli can advance the understanding of how the brain encodes semantic information and contribute to semantic decoding in brain-computer interface (...
-
Article
Open AccessDomain wall magnetic tunnel junction-based artificial synapses and neurons for all-spin neuromorphic hardware
We report a breakthrough in the hardware implementation of energy-efficient all-spin synapse and neuron devices for highly scalable integrated neuromorphic circuits. Our work demonstrates the successful execut...
-
Article
Open AccessIn vivo phage display identifies novel peptides for cardiac targeting
Heart failure remains a leading cause of mortality. Therapeutic intervention for heart failure would benefit from targeted delivery to the damaged heart tissue. Here, we applied in vivo peptide phage display c...