216 Result(s)

Article

The mediating effect of bullying on parental–peer support matching and NSSI behaviour among adolescents

Being subjected to bullying is a significant risk factor for non-suicidal self-injury (NSSI) among adolescents. Parental support, peer support, and social connectedness play protective roles in mitigating NSSI...

Huaqiang Liu, Zhensong Lan, Xuefang Huang, Qing Wang, Fafang Deng… in BMC Public Health (2024)

Article

Effect of ultrasound-guided injection of botulinum toxin type A into shoulder joint cavity on shoulder pain in poststroke patients: study protocol for a randomized controlled trial

Hemiplegic shoulder pain (HSP) is a common complication after stroke. It severely affects the recovery of upper limb motor function. Early shoulder pain in hemiplegic patients is mainly neuropathic caused by c...

Peng Zheng, Yu Shi, Hang Qu, Meng lin Han, Zhi qiang Wang, Qing Zeng, Manxu Zheng… in Trials (2024)

Article

A novel variant in the SLCO2A1 gene in a Chinese patient with chronic gastroenteropathy and primary hypertrophic osteoarthropathy

Chronic enteropathy associated with SLCO2A1 gene (CEAS) results from loss-of-function variants in SLCO2A1, which encodes the prostaglandin transporter (PGT). CEAS follows an autosomal recessive inheritance patter...

Yimin Dai, Miao He, Hui Xu, Bei Tan, Weixun Zhou… in Orphanet Journal of Rare Diseases (2024)

Article

First-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular exploratory, phase II trial

Metastatic pancreatic cancer (mPC) has a dismal prognosis. Herein, we conducted a prospective, multicentre, single-arm, phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combinat...

Huizi Sha, Fan Tong, Jiayao Ni, Yi Sun… in Signal Transduction and Targeted Therapy (2024)

Article

DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure

DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understo...

Ming**g Yan, Junpeng Gao, Ming Lan, Que Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Sustainable Implementation of Physician-Pharmacist Collaborative Clinics for Diabetes Management in Primary Healthcare Centers: A Qualitative Study

Although physician-pharmacist collaborative clinics for diabetes management have been shown to be effective and cost-effective worldwide, there is limited understanding of the factors that influence their sust...

Jie **ao, Shuting Huang, Qing Wang… in Journal of Epidemiology and Global Health (2024)

Article

Associated lifestyle factors of elevated plasma aldosterone concentration in community population, gender-stratified analysis of a cross-sectional survey

Aldosterone plays important parts in development of cardio-metabolic diseases as end product of renin-angiotensin-aldosterone system. However, factors elevating circulating aldosterone are not clear, and lifes...

Adalaiti Maitituersun, Mulalibieke Heizhati, Nanfang Li, Lin Gan… in BMC Public Health (2024)

Article

Clinical and genetic characteristics of Chinese patients diagnosed with chronic enteropathy associated with SLCO2A1 gene

Chronic enteropathy associated with SLCO2A1 gene is a rare intestinal disease caused by loss-of-function SLCO2A1 mutations, with clinical and genetic characteristics remaining largely unknown, especially in Chine...

Qing Shang, Yimin Dai, **gyi Huang, Wei Liu… in Orphanet Journal of Rare Diseases (2024)

Article

Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1

Develo** a mucosal vaccine against SARS-CoV-2 is critical for combatting the epidemic. Here, we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a t...

**an Li, Mengxin Xu, **gyi Yang, Li Zhou… in Signal Transduction and Targeted Therapy (2024)

Article

Exploration of treatment in childhood Langerhans cell histiocytosis based on inflammatory and malignant symptoms: a pilot study

Multisystem childhood Langerhans cell histiocytosis (LCH) patients, especially those with risk organ (RO) involved, had not been satisfactorily treated under the international traditional schemes as high incid...

Hui-ling Lin, Qing-qing Zheng, Ru-lin Huang, Rong Hu… in Orphanet Journal of Rare Diseases (2024)

Article

A new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers

Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new humanized anti-Trop2 antibody named hIMB1636, and designated ...

Dan-dan Zhou, **ao-tian Zhai, Lan-wen Zhang, Zi-hui **e… in npj Precision Oncology (2024)

Article

Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus

Severe psychiatric illnesses, for instance schizophrenia, and affective diseases or autism spectrum disorders, have been associated with cognitive impairment and perturbed excitatory-inhibitory balance in the ...

Yasmina Curto, Héctor Carceller, Patrycja Klimczak… in Molecular Psychiatry (2024)

Article

Spatial-temporal drivers and incidence heterogeneity of hemorrhagic fever with renal syndrome transmission in Shandong Province, China, 2016–2022

Hemorrhagic fever with renal syndrome (HFRS) signals a recurring risk in Eurasia in recent years owing to its continued rise in case notifications and the extension of geographical distribution. This study was...

Qing Duan, Yao Wang, **aolin Jiang, Shujun Ding, Yuwei Zhang… in BMC Public Health (2024)

Article

Cervical lymph node metastasis prediction from papillary thyroid carcinoma US videos: a prospective multicenter study

Prediction of lymph node metastasis (LNM) is critical for individualized management of papillary thyroid carcinoma (PTC) patients to avoid unnecessary overtreatment as well as undesired under-treatment. Artifi...

Ming-Bo Zhang, Zhe-Ling Meng, Yi Mao, Xue Jiang, Ning Xu, Qing-Hua Xu… in BMC Medicine (2024)

Article

Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization

Ossification of the Posterior Longitudinal Ligament (OPLL) is a degenerative hyperostosis disease characterized by the transformation of the soft and elastic vertebral ligament into bone, resulting in limited ...

Longqing Wang, Wenhao Jiang, Siyuan Zhao, Dong **e, Qing Chen, Qi Zhao… in Bone Research (2024)

Article

Correction: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Bo-Gyeom Kim, Gakyung Kim, Yoshinari Abe, Pino Alonso… in Molecular Psychiatry (2024)

Article

White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predo...

Bo-Gyeom Kim, Gakyung Kim, Yoshinari Abe, Pino Alonso… in Molecular Psychiatry (2024)

Article

Transcranial alternating current stimulation improves quality of life in Parkinson’s disease: study protocol for a randomized, double-blind, controlled trial

The neural cells in the brains of patients with Parkinson’s disease (PWP) display aberrant synchronized oscillatory activity within the beta frequency range. Additionally, enhanced gamma oscillations may serve...

Hong-yu Zhang, Ting-ting Hou, Zhao-hui **, Tian Zhang, Yi-heng Wang… in Trials (2024)

Article

Predictors of quitting support from nonsmoking mothers for smoking fathers: a cross-sectional study from Chinese pupils’ families

Quitting support from smokers’ partners can predict quit attempts and smoking abstinence but research on factors that predict such support has been limited. To add more evidence for partner support and the imp...

Nan Jiang, Ling-ling Huo, Zeng-zhi Zhang, Yi-qing Huang, Yu-hua Li… in BMC Public Health (2024)

Article

TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro

There is a lack of effective therapeutic strategies for amyotrophic lateral sclerosis (ALS); therefore, drug repurposing might provide a rapid approach to meet the urgent need for treatment.

Qing-Qing Duan, Han Wang, Wei-Ming Su, **ao-**g Gu, **ao-Fei Shen… in BMC Medicine (2024)