75 Result(s)

Article

First-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular exploratory, phase II trial

Metastatic pancreatic cancer (mPC) has a dismal prognosis. Herein, we conducted a prospective, multicentre, single-arm, phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combinat...

Huizi Sha, Fan Tong, Jiayao Ni, Yi Sun… in Signal Transduction and Targeted Therapy (2024)

Article

DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure

DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understo...

Ming**g Yan, Junpeng Gao, Ming Lan, Que Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1

Develo** a mucosal vaccine against SARS-CoV-2 is critical for combatting the epidemic. Here, we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a t...

**an Li, Mengxin Xu, **gyi Yang, Li Zhou… in Signal Transduction and Targeted Therapy (2024)

Article

A new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers

Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new humanized anti-Trop2 antibody named hIMB1636, and designated ...

Dan-dan Zhou, **ao-tian Zhai, Lan-wen Zhang, Zi-hui **e… in npj Precision Oncology (2024)

Article

A novel alternative for pyrogen detection based on a transgenic cell line

Pyrogen, often as a contaminant, is a key indicator affecting the safety of almost all parenteral drugs (including biologicals, chemicals, traditional Chinese medicines and medical devices). It has become a go...

Qing He, Chuan-Fei Yu, Gang Wu, Kai-Qin Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Surgical treatment for right-side aortic arch concomitant with Kommerell’s diverticulum: techniques selection and follow-up results

Right-side aortic arch concomitant with Kommerell’s diverticulum (KD) is a rare and complex ailment, and there is no consensus on the optimal strategy to deal with this congenital anomaly. We retrospectively a...

Yali Wang, Shuchun Li, Min **, Yunxing Xue… in European Journal of Medical Research (2024)

Article

Comparison of different internal fixation models in ankle arthrodesis using 3D finite-element analysis

The purpose of this study is to use three-dimensional finite-element analysis to better understand the biomechanical features of various internal fixators for ankle arthrodesis.

Bo Feng, Qing-bo Gao, Guang-ming Dai, Ke-cheng Niu… in European Journal of Medical Research (2023)

Article

Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and nivolumab–chemotherapy (N/C) combinations based on PD-L1 expression. Eligible patients exh...

Si-Yang Liu, Song Dong, Xue-Ning Yang… in Signal Transduction and Targeted Therapy (2023)

Article

RNA modification in cardiovascular disease: implications for therapeutic interventions

Cardiovascular disease (CVD) is the leading cause of death in the world, with a high incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable in cell, maintaining cell homeosta...

Cong Wang, Xuyang Hou, Qing Guan, Huiling Zhou… in Signal Transduction and Targeted Therapy (2023)

Article

EBUS-GS with the GeneXpert MTB/RIF assay for diagnosis of Mycobacterium tuberculosis infection of isolated pulmonary nodules

Investigate the use of endobronchial ultrasonography with a guide sheath (EBUS-GS) combined with Gene Xpert MTB/RIF (Xpert) for diagnosis of Mycobacterium tuberculosis (MTB) infection in isolated pulmonary nodule...

Jie Cao, Ye Gu, **ao-cui Wu, Li-** Cheng… in European Journal of Medical Research (2023)

Article

Risk-stratified multi-round PSA screening for prostate cancer integrating the screening reference level and subgroup-specific progression indicators

Although prostate-specific antigen (PSA) is widely used in prostate cancer (PCa) screening, nearly half of PCa cases are missed and less than one-third of cases are non-lethal. Adopting diagnostic criteria in ...

**aomin Liu, Yu Zhang, Hongyuan Duan, Lei Yang… in European Journal of Medical Research (2023)

Article

Comprehensive analysis of angiogenesis pattern and related immune landscape for individual treatment in osteosarcoma

Postoperative recurrence and metastasis are the main reasons for the poor prognosis of osteosarcoma (OS). Currently, an ideal predictor for not only prognosis but also drug sensitivity and immunotherapy respon...

Zhuangyao Liao, Ming Li, Guoming Wen, Kun Wang, Dengbo Yao… in npj Precision Oncology (2023)

Article

Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis

T lymphopenia, occurring in the early phase of sepsis in response to systemic inflammation, is commonly associated with morbidity and mortality of septic infections. We have previously shown that a sufficient ...

Sheng-yuan Zhang, Qiu-** Xu, Li-na Shi… in Signal Transduction and Targeted Therapy (2023)

Article

Laser treatment for Cafe-au-lait Macules: a systematic review and meta-analysis

Nowadays, laser is the mainstay treatment for cafe-au-lait macules (CALMs), but no systematic review has been published to demonstrate the overall efficacy and it’s still controversial which type of laser is o...

Zi-Zhen Guo, Zhi-Chao Wang, Dun Wang, Ling-Ling Ge… in European Journal of Medical Research (2023)

Article

Neutralizing antibodies against SARS-CoV-2 virus after vaccination in patients with neurofibromatosis type 1

Qiao-ling Ruan, Zhi-chao Wang, Cheng-jiang Wei… in Signal Transduction and Targeted Therapy (2023)

Article

CACA guidelines for ultrasound hyperthermia for oral and maxillofacial head and neck squamous cell carcinoma

Most of the patients with oral and maxillofacial malignancy are in the middle and advanced stages at diagnosis and the incidence rate is increasing in recent years. Chemotherapy alone is difficult to benefit t...

Houyu Ju, Jiawei Zheng, Moyi Sun, Zhangui Tang, Daoke Yang… in Holistic Integrative Oncology (2023)

Article

Current understanding of adenoid cystic carcinoma in the gene expression and targeted therapy

Adenoid Cystic Carcinoma (ACC) has been considered as a "quiet" tumor. It is typically malignancy arising from exocrine glands with poor long-term prognosis due to high rate of recurrence and distant metastasi...

Quan-Quan Lin, **-Long Sun, Feng Wang, Hai-Zhong Zhang… in Holistic Integrative Oncology (2023)