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Article
Observation of carbonaceous mesophase behaviors in phenolated sawdust using polarized light microscopy
The phenolated sawdust had been proved to be a new kind of carbon precursor with excellent self-sintering ability. As a part of research on characterizing the structure and composition of the new kind of carbo...
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Article
Aggregation of α-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine
Parkinson’s disease (PD) is a neurodegenerative disease characterized by the selective loss of dopamine (DA) neurons and the presence of α-synuclein (AS) aggregates as Lewy bodies (LBs) in the remaining substa...
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Article
The bio-functional role of calcium in mesoporous silica xerogels on the responses of osteoblasts in vitro
Mesoporous silica xerogels with various amount of calcium (0, 5, 10 and 15%, named m-SXC0, m-SXC5, m-SXC10 and m-SXC15, respectively) were synthesized by template sol–gel methods, and cell responses to m-SXCs ...
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Article
Effect of size on the cellular endocytosis and controlled release of mesoporous silica nanoparticles for intracellular delivery
Due to the unique physicochemical properties and membrane-permeable capacity, mesoporous silica nanoparticles (MSNs) are considered as an ideal carrier for intracellular delivery. Herein, we endeavored to addr...
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Article
Open AccessCalcium ion-induced formation of β-sheet/-turn structure leading to alteration of osteogenic activity of bone morphogenetic protein-2
Preserving bioactivity of bone morphogenetic protein 2 (BMP-2) still remains a challenge in protein-based therapy. It is not known how Ca2+ released from extracellular matrix or existing in physiological environm...
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Article
Open AccessThe value of intraoperative intracranial pressure monitoring for predicting re-operation using salvage decompressive craniectomy after craniotomy in patients with traumatic mass lesions
The risk factors of predicting the need for postoperative decompressive craniectomy due to intracranial hypertension after primary craniotomy remain unclear. This study aimed to investigate the value of intrao...
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Article
Open AccessProspective randomized evaluation of therapeutic decompressive craniectomy in severe traumatic brain injury with mass lesions (PRECIS): study protocol for a controlled trial
For cases of severe traumatic brain injury, during primary operation, neurosurgeons usually face a dilemma of whether or not to remove the bone flap after mass lesion evacuation. Decompressive craniectomy, whi...
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Article
Diagnostic performance of diffusion-weighted magnetic resonance imaging in differentiating human renal lesions (benignity or malignancy): a meta-analysis
This study aims to quantitatively evaluate the potential of diffusion-weighted magnetic resonance imaging (DW-MRI) for differentiating malignant and benign human renal lesions.
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Article
Biochemical characterization of a thermostable DNA ligase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5
DNA ligases are essential enzymes for DNA replication, repair, and recombination processes by catalyzing a nick-joining reaction in double-stranded DNA. The genome of the hyperthermophilic euryarchaeon Thermococc...
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Article
Open AccessAbnormally increased carotid intima media-thickness and elasticity in patients with Morquio A disease
Cardiovascular disease frequently causes morbidity and mortality in mucopolysaccharidoses (MPS); however, cardiovascular anatomy and dysfunction in MPS IVA (Morquio A disease) is not well described. Consequent...
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Article
Biodegradable polyethylene glycol hydrogels for sustained release and enhanced stability of rhGALNS enzyme
Mucopolysaccharidosis IVA (Morquio A disease) is a genetic disorder caused by deficiency of N-acetylgalactosamine-6-sulfate-sulfatase (GALNS), leading to accumulation of keratan sulfate and chondroitin-6-sulfate ...
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Article
Open AccessUmbilical mesenchymal stem cell-derived extracellular vesicles as enzyme delivery vehicle to treat Morquio A fibroblasts
Mucopolysaccharidosis IVA (Morquio A syndrome) is a lysosomal storage disease caused by the deficiency of enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS), which results in the accumulation of the glycosa...
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Article
Open AccessAuthor Correction: Calcium ion-induced formation of β-sheet/-turn structure leading to alteration of osteogenic activity of bone morphogenetic protein-2
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Identification of a novel bifunctional uracil DNA glycosylase from Thermococcus barophilus Ch5
Genomes of hyperthermophiles are facing a severe challenge due to increased deamination rates of cytosine induced by high temperature, which could be counteracted by base excision repair mediated by uracil DNA...
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Article
Experimental and analytical investigation of the potential of carbon fibres for use in multifunctional batteries
Carbon fibres have been extensively investigated for their promising potential as anodes or current collectors in next-generation integrated batteries. However, the exact reasons for the distinct lithium-ion b...
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Article
Open AccessSpatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas
Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal brain tumors that primarily occur in pediatric and adult patients, respectively. Both tumors exhibit significant heterogene...
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Article
Effect of Statin Treatment in Patients with Aneurysmal Subarachnoid Hemorrhage: A Network Meta-Analysis
There are knowledge gaps regarding the relative efficacy of statins for aneurysmal subarachnoid hemorrhage (aSAH). This study aims to examine the comparative effectiveness and determine the ranking of differen...
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Article
Association of hemoglobin drift and outcomes in patients with aneurysmal subarachnoid hemorrhage
The relationship between in-hospital hemoglobin (Hb) drift and outcomes in patients undergoing surgical clip** for aneurysmal subarachnoid hemorrhage (aSAH) is not well studied. This study aims to investigat...
