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    Article

    Identification of a novel bifunctional uracil DNA glycosylase from Thermococcus barophilus Ch5

    Genomes of hyperthermophiles are facing a severe challenge due to increased deamination rates of cytosine induced by high temperature, which could be counteracted by base excision repair mediated by uracil DNA...

    Likui Zhang, Donghao Jiang, Qi Gan, Haoqiang Shi… in Applied Microbiology and Biotechnology (2021)

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    Article

    Biochemical characterization of a thermostable DNA ligase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5

    DNA ligases are essential enzymes for DNA replication, repair, and recombination processes by catalyzing a nick-joining reaction in double-stranded DNA. The genome of the hyperthermophilic euryarchaeon Thermococc...

    Haoqiang Shi, Yanchao Huang, Qi Gan, Mianwen Rui… in Applied Microbiology and Biotechnology (2019)