524 Result(s)

Article

Correction: Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFβ/SMAD signalling during gliomagenesis

Xuexia Zhou, Xuebing Li, Run Wang, Dan Hua, Cuiyun Sun, Lin Yu… in Cell Death & Disease (2024)

Article

Phase separation of RNF214 promotes the progression of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and the expression and function of an uncharacterized protein RNF214 in HCC are still unknown. Phase separation has recently been obse...

Zheng-Jie He, Ke He, Song-Wang Cai, Rui Zhang, Zhong-Bao Shao… in Cell Death & Disease (2024)

Article

S100A8/A9^hi neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis

S100a8/a9, largely released by polymorphonuclear neutrophils (PMNs), belongs to the S100 family of calcium-binding proteins and plays a role in a variety of inflammatory diseases. Although S100a8/a9 has been r...

Yanghanzhao Wang, Yuxin Shi, Yuwen Shao, **hua Lu, Hao Zhang… in Cell Death & Disease (2024)

Article

TNIP3 protects against pathological cardiac hypertrophy by stabilizing STAT1

Pathological cardiac hypertrophy is one of the major risk factors of heart failure and other cardiovascular diseases. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown....

Hongjie Shi, Yongjie Yu, Dajun Li, Kun Zhu, Xu Cheng, Tengfei Ma… in Cell Death & Disease (2024)

Article

Syrosingopine and UK5099 synergistically suppress non-small cell lung cancer by activating the integrated stress response

Non-small cell lung cancer (NSCLC) presents a global health challenge due to its low five-year survival rates, underscoring the need for novel therapeutic strategies. Our research explored the synergistic mech...

Yiman Li, Yan Song, Zhi**g Shi, Huijie Hou, Yang Yu, Fei Pan… in Cell Death & Disease (2024)

Article

Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival

Low glucose is a common microenvironment for rapidly growing solid tumors, which has developed multiple approaches to survive under glucose deprivation. However, the specific regulatory mechanism remains large...

Miaomiao Li, Wen**g Huang, Yuan Zhang, Yue Du, Shan Zhao… in Cell Death & Disease (2024)

Article

HOXD10 attenuates renal fibrosis by inhibiting NOX4-induced ferroptosis

In chronic kidney disease (CKD), renal fibrosis is an unavoidable result of various manifestations. However, its pathogenesis is not yet fully understood. Here, we revealed the novel role of Homeobox D10 (HOXD...

**n Li, Tian-Kui Ma, Pu Wang, Hang Shi, Sang Hai, Yu Qin, Yun Zou… in Cell Death & Disease (2024)

Article

Retraction Note: Deregulated AJAP1/β-catenin/ZEB1 signaling promotes hepatocellular carcinoma carcinogenesis and metastasis

Jihua Han, Changming **e, Tiemin Pei, Jiabei Wang, Yaliang Lan… in Cell Death & Disease (2024)

Article

Targeting the mitochondrial protein YME1L to inhibit osteosarcoma cell growth in vitro and in vivo

Exploring novel diagnostic and therapeutic biomarkers is extremely important for osteosarcoma. YME1 Like 1 ATPase (YME1L), locating in the mitochondrial inner membrane, is key in regulating mitochondrial plast...

Xu Sun, Ce Shi, ** Dai, Mei-Qing Zhang, Dong-Sheng Pei, Lei Yang in Cell Death & Disease (2024)

Article

E3 ubiquitin ligase UBR5 promotes gemcitabine resistance in pancreatic cancer by inducing O-GlcNAcylation-mediated EMT via destabilization of OGA

Pancreatic cancer (PC) is among the deadliest malignancies, with an extremely poor diagnosis and prognosis. Gemcitabine (GEM) remains the first-line drug for treating PC; however, only a small percentage of pa...

Yunyan Du, Zhangjian Yang, Hao Shi, Zhihan Chen, Rong Chen… in Cell Death & Disease (2024)

Article

Histidine re-sensitizes pediatric acute lymphoblastic leukemia to 6-mercaptopurine through tetrahydrofolate consumption and SIRT5-mediated desuccinylation

Despite progressive improvements in the survival rate of pediatric B-cell lineage acute lymphoblastic leukemia (B-ALL), chemoresistance-induced disease progression and recurrence still occur with poor prognosi...

Na Dong, Hui-**an Ma, Xue-Qin Liu, Dong Li, Ling-Hong Liu, Qing Shi… in Cell Death & Disease (2024)

Article

TAB182 regulates glycolytic metabolism by controlling LDHA transcription to impact tumor radiosensitivity

Metabolic reprogramming, a hallmark of cancer, is closely associated with tumor development and progression. Changes in glycolysis play a crucial role in conferring radiation resistance to tumor cells. How rad...

Shi Chen, Da-Fei **e, Saiyu Li, **hua Luo, Yang Han, Hejiang Guo… in Cell Death & Disease (2024)

Article

A first-in-class TIMM44 blocker inhibits bladder cancer cell growth

Mitochondria play a multifaceted role in supporting bladder cancer progression. Translocase of inner mitochondrial membrane 44 (TIMM44) is essential for maintaining function and integrity of mitochondria. We h...

Lifeng Zhang, **aokai Shi, Lei Zhang, Yuanyuan Mi, Li Zuo… in Cell Death & Disease (2024)

Article

Retraction Note: GRP78 determines glioblastoma sensitivity to UBA1 inhibition-induced UPR signaling and cell death

Guanzheng Liu, Jiefeng Yu, Runqiu Wu, Lin Shi, Xu Zhang… in Cell Death & Disease (2024)

Article

Deciphering the tumor immune microenvironment of imatinib-resistance in advanced gastrointestinal stromal tumors at single-cell resolution

The heterogeneous nature of tumors presents a considerable obstacle in addressing imatinib resistance in advanced cases of gastrointestinal stromal tumors (GIST). To address this issue, we conducted single-cel...

Xuechao Liu, **g Yu, Yi Li, Hailei Shi, Xuelong Jiao, **aodong Liu… in Cell Death & Disease (2024)

Article

KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC

Immunotherapy has become a prominent first-line cancer treatment strategy. In non-small cell lung cancer (NSCLC), the expression of PD-L1 induces an immuno-suppressive effect to protect cancer cells from immun...

**ghan Li, Daiwang Shi, Siyi Li, **ang Shi, Yu Liu, Yi Zhang… in Cell Death & Disease (2024)

Article

HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy

Impaired fatty acid oxidation (FAO) is a prominent feature of metabolic remodeling observed in pathological myocardial hypertrophy. Hepatocyte nuclear factor 4alpha (HNF4α) is closely associated with FAO in bo...

Yuxing Hou, Pengxi Shi, Haiyang Du, Chenghao Zhu, Chao Tang… in Cell Death & Disease (2024)

Article

The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity

Discovery of new small molecules that can activate distinct programmed cell death pathway is of significant interest as a research tool and for the development of novel therapeutics for pathological conditions...

Jascinta P. Santavanond, Yu-Hsin Chiu, Rochelle Tixeira… in Cell Death & Disease (2024)

Article

Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis

Gasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However, the role of posttranslational modifications (PTMs) in GSDMD...

Weilv Xu, Qiao **, **nyue Li, Danyue Li, **nyu Fu, Nan Chen… in Cell Death & Disease (2024)

Article

CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma

Abnormal expression of Cylindromatosis (CYLD), a tumor suppressor molecule, plays an important role in tumor development and treatment. In this work, we found that CYLD binds to class I histone deacetylases (H...

Yueshuo Li, Chenxing Yang, Longlong **e, Feng Shi, Min Tang… in Cell Death & Disease (2024)