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    Time Dimension Influences Severity of Stroke and Heightened Immune Response in Mice

    Ischemic stroke is caused by obstructed cerebral blood flow, which results in neurological injury and poor outcomes. Pro-inflammatory signaling from both residential and infiltrating immune cells potentiates c...

    Pradip K. Kamat, Mohammad Badruzzaman Khan… in Translational Stroke Research (2023)

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    Streptozotocin Intracerebroventricular-Induced Neurotoxicity and Brain Insulin Resistance: a Therapeutic Intervention for Treatment of Sporadic Alzheimer’s Disease (sAD)-Like Pathology

    Alzheimer’s disease (AD) is a neurodegenerative disorder that is remarkably characterized by pathological hallmarks which include amyloid plaques, neurofibrillary tangles, neuronal loss, and progressive cognit...

    Pradip K. Kamat, Anuradha Kalani, Shivika Rai, Santosh Kumar Tota… in Molecular Neurobiology (2016)

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    Hydrogen Sulfide Ameliorates Homocysteine-Induced Alzheimer’s Disease-Like Pathology, Blood–Brain Barrier Disruption, and Synaptic Disorder

    Elevated plasma total homocysteine (Hcy) level is associated with an increased risk of Alzheimer’s disease (AD). During transsulfuration pathways, Hcy is metabolized into hydrogen sulfide (H2S), which is a synapt...

    Pradip K. Kamat, Philip Kyles, Anuradha Kalani, Neetu Tyagi in Molecular Neurobiology (2016)

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    Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

    Synapses are formed by interneuronal connections that permit a neuronal cell to pass an electrical or chemical signal to another cell. This passage usually gets damaged or lost in most of the neurodegenerative...

    Pradip K. Kamat, Anuradha Kalani, Shivika Rai, Supriya Swarnkar… in Molecular Neurobiology (2016)

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    Epigenetic impact of curcumin on stroke prevention

    The epigenetic impact of curcumin in stroke and neurodegenerative disorders is curiosity-arousing. It is derived from Curcuma longa (spice), possesses anti-oxidative, anti-inflammatory, anti-lipidemic, neuro-prot...

    Anuradha Kalani, Pradip K. Kamat, Komal Kalani, Neetu Tyagi in Metabolic Brain Disease (2015)

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    Molecular and Cellular Mechanism of Okadaic Acid (OKA)-Induced Neurotoxicity: A Novel Tool for Alzheimer’s Disease Therapeutic Application

    Okadaic acid (OKA), a polyether C38 fatty acid toxin extracted from a black sponge Hallichondria okadaii, is a potent and selective inhibitor of protein phosphatase, PP1 and PP2A. OKA has been proved to be a powe...

    Pradip K. Kamat, Shivika Rai, Supriya Swarnkar, Rakesh Shukla… in Molecular Neurobiology (2014)

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    Article

    Nutri-epigenetics Ameliorates Blood–Brain Barrier Damage and Neurodegeneration in Hyperhomocysteinemia: Role of Folic Acid

    Epigenetic mechanisms underlying nutrition (nutrition epigenetics) are important in understanding human health. Nutritional supplements, for example folic acid, a cofactor in one-carbon metabolism, regulate ep...

    Anuradha Kalani, Pradip K. Kamat, Srikanth Givvimani… in Journal of Molecular Neuroscience (2014)