71 Result(s)

Article

Correction: Exploring the Effects of Ixekizumab on Pain in Patients with Ankylosing Spondylitis Based on Objective Measures of Inflammation: Post Hoc Analysis from a Large Randomized Clinical Trial

Kurt de Vlam, Walter P. Maksymowych, Gaia Gallo, Proton Rahman… in Rheumatology and Therapy (2024)

Article

Exploring the Effects of Ixekizumab on Pain in Patients with Ankylosing Spondylitis Based on Objective Measures of Inflammation: Post Hoc Analysis from a Large Randomized Clinical Trial

The objective of this analysis is to evaluate the improvement in spinal pain with ixekizumab, placebo, and adalimumab based on objective measures of inflammation response in patients with ankylosing spondyliti...

Kurt de Vlam, Walter P. Maksymowych, Gaia Gallo, Proton Rahman… in Rheumatology and Therapy (2024)

Article

Effectiveness and safety of polyacrylamide hydrogel injection for knee osteoarthritis: results from a 12-month follow up of an open-label study

There are few effective osteoarthritis (OA) therapies. A novel injectable polyacrylamide hydrogel (iPAAG) previously demonstrated efficacy and safety up to week 26 in an open-label study of knee OA. Here we re...

Henning Bliddal, Jannie Beier… in Journal of Orthopaedic Surgery and Research (2024)

Article

Effect size varies based on calculation method and may affect interpretation of treatment effect: an illustration using randomised clinical trials in osteoarthritis

To illustrate how (standardised) effect sizes (ES) vary based on calculation method and to provide considerations for improved reporting.

Thomas J. Schnitzer, Philip G. Conaghan, Francis Berenbaum… in Advances in Rheumatology (2024)

Article

Benefits of Autoantibody Enrichment in Early Rheumatoid Arthritis: Analysis of Efficacy Outcomes in Four Pooled Abatacept Trials

The efficacy of abatacept is enhanced in anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF)-positive versus -negative patients with rheumatoid arthritis (RA). Four early RA abatacept trials ...

Kaleb Michaud, Philip G. Conaghan, Sang Hee Park… in Rheumatology and Therapy (2023)

Article

Real-world evidence: new opportunities for osteoporosis research. Recommendations from a Working Group from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)

This narrative review summarises the recommendations of a Working Group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) for the co...

Rebecca J. Moon, Jean-Yves Reginster, Nasser M. Al-Daghri… in Osteoporosis International (2023)

Article

Association between outpatient follow-up and incidence of revision after knee and hip replacements: a population-based cohort study

Follow-up visits 5 or 7 years after surgery were recommended for people having primary hip or knee replacement. The benefits of this practice to patients and the healthcare system, however, have not yet been s...

Rafael Pinedo-Villanueva, Spyros Kolovos, Edward Burn… in BMC Musculoskeletal Disorders (2023)

Article

Comparison of 3D quantitative osteoarthritis imaging biomarkers from paired CT and MR images: data from the IMI-APPROACH study

MRI bone surface area and femoral bone shape (B-score) measures have been employed as quantitative endpoints in DMOAD clinical trials. Computerized Tomography (CT) imaging is more commonly used for 3D visualiz...

Alan Brett, Michael A. Bowes, Philip G. Conaghan in BMC Musculoskeletal Disorders (2023)

Article

Develo** an Outcome Measures in Rheumatology (OMERACT) Core set of Outcome Measures for FOot and ankle disorders in RheumaTic and musculoskeletal diseases (COMFORT): core domain set study protocol

Foot and ankle involvement is common in rheumatic and musculoskeletal diseases (RMDs). High-quality evidence is lacking to determine the effectiveness of treatments for these disorders. Heterogeneity in the ou...

Lara S. Chapman, Anthony C. Redmond, Caroline A. Flurey, Pamela Richards… in Trials (2023)

Article

Multimodal Multidisciplinary Management of Patients with Moderate to Severe Pain in Knee Osteoarthritis: A Need to Meet Patient Expectations

Knee osteoarthritis (OA) is one of the most common and disabling medical conditions. In the case of moderate to severe pain, a single intervention may not be sufficient to allay symptoms and improve quality of...

Nicola Veronese, Cyrus Cooper, Olivier Bruyère, Nasser M. Al-Daghri, Jaime Branco… in Drugs (2022)

Article

Improved Treatment Effect of Triamcinolone Acetonide Extended-Release in Patients with Concordant Baseline Pain Scores on the Average Daily Pain and Western Ontario and McMaster Universities Osteoarthritis Index Pain Scales

A phase 3 randomized controlled study comparing triamcinolone acetonide extended-release (TA-ER) to conventional TA crystalline suspension (TAcs) reported variable efficacy results. Enrollment criteria may hav...

Edgar Ross, Nathaniel P. Katz, Philip G. Conaghan, Alan Kivitz… in Pain and Therapy (2022)

Article

Prediction of flare following remission and treatment withdrawal in early rheumatoid arthritis: post hoc analysis of a phase IIIb trial with abatacept

Drug-free remission is a desirable goal in rheumatoid arthritis (RA) for both patients and clinicians. The aim of this post hoc analysis was to investigate whether clinical and magnetic resonance imaging (MRI)...

Harris A. Ahmad, Joshua F. Baker, Philip G. Conaghan… in Arthritis Research & Therapy (2022)

Article

Impact of tanezumab on health status, non-work activities and work productivity in adults with moderate-to-severe osteoarthritis

To evaluate the impact of tanezumab on health status, non-work activities, and work productivity in a pooled analysis of two large phase 3 osteoarthritis (OA) studies.

Philip G. Conaghan, Lucy Abraham, Lars Viktrup, Paul Cislo in BMC Musculoskeletal Disorders (2022)

Article

Single and Composite Endpoints of Within-Patient Improvement in Symptoms: Pooled Tanezumab Data in Patients with Osteoarthritis

Combining measures of key core domains (especially pain and function) into a composite endpoint that requires each patient to meet a threshold of improvement for each domain provides information on multiple as...

Thomas J. Schnitzer, Francis Berenbaum, Philip G. Conaghan… in Rheumatology and Therapy (2021)

Article

Prospects for Therapies in Osteoarthritis

Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatme...

Asim Ghouri, Philip G. Conaghan in Calcified Tissue International (2021)

Article

Individual Participant Symptom Responses to Intra-Articular Lorecivivint in Knee Osteoarthritis: Post Hoc Analysis of a Phase 2B Trial

Established thresholds for patient-reported outcomes (PROs) provide clinically relevant responder data from trials. Lorecivivint (LOR) is an intra-articular (IA) therapy in development for knee osteoarthritis ...

Jeyanesh R. S. Tambiah, Sarah Kennedy… in Rheumatology and Therapy (2021)

Article

Upadacitinib in Rheumatoid Arthritis: A Benefit–Risk Assessment Across a Phase III Program

Treating to a target of clinical remission or low disease activity is an important principle for managing rheumatoid arthritis (RA). Despite the availability of biologic disease-modifying antirheumatic drugs (...

Philip G. Conaghan, Eduardo Mysler, Yoshiya Tanaka… in Drug Safety (2021)

Article

Correction to: Osteoarthritis Preoperative Package for care of Orthotics, Rehabilitation, Topical and oral agent Usage and Nutrition to Improve ouTcomes at a Year (OPPORTUNITY); a feasibility study protocol for a randomised controlled trial

After publication of our article [1] we have been notified that two of the author names have been mistakenly removed from the authorship list: Colin R. Howie and Nicholas D. Clement.

A. Hamish R. W. Simpson, Colin R. Howie, Elaine Kinsella, David F. Hamilton… in Trials (2020)