3 Result(s)
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Article
P. Aitana Azurmendi
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Article
Open AccessHydrophobic interactions dominate the recognition of a KRAS G12V neoantigen
Specificity remains a major challenge to current therapeutic strategies for cancer. Mutation associated neoantigens (MANAs) are products of genetic alterations, making them highly specific therapeutic targets....
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Open AccessThe rapid and highly parallel identification of antibodies with defined biological activities by SLISY
The therapeutic applications of antibodies are manifold and the emergence of SARS-CoV-2 provides a cogent example of the value of rapidly identifying biologically active antibodies. We describe an approach cal...
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Open AccessStructural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens
Chimeric antigen receptor (CAR) T cells have emerged as a promising class of therapeutic agents, generating remarkable responses in the clinic for a subset of human cancers. One major challenge precluding the ...
