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Article
Diagnosis of retinopathy in children younger than 12 years of age: implications for the diabetic eye screening guidelines in the UK
To assess whether the current starting age of 12 is suitable for diabetic retinopathy (DR) screening and whether diabetes duration should be taken into account when deciding at what age to start screening pati...
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Article
Medical management of diabetic retinopathy: fenofibrate and ACCORD Eye studies
The approach of all ophthalmologists, diabetologists and general practitioners seeing patients with diabetic retinopathy should be that good control of blood glucose, blood pressure and plasma lipids are all e...
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Article
Diabetic retinopathy and blockade of the renin–angiotensin system: new data from the DIRECT study programme
The pathogenesis and medical management of diabetic retinopathy is reviewed. The importance of good control of blood glucose and blood pressure remain key elements in the prevention and treatment of diabetic r...
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Article
Management of diabetic retinopathy: could lipid-lowering be a worthwhile treatment modality?
Diabetic eye disease confers substantial burden on the patient quality of life. Current therapeutic strategies indicate an unmet clinical need for preventive therapy. Tight control of blood pressure and glycae...
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Article
Homocysteine, folates, and the eye
Plasma homocysteine has been identified as a risk factor for arterial disease, retinal artery and vein occlusions, and other common eye diseases. The value of treating an elevated plasma homocysteine with foli...
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Article
Pain response and follow-up of patients undergoing panretinal laser photocoagulation with reduced exposure times
We performed a study of laser panretinal photocoagulation in 20 patients with proliferative retinopathy. We compared short exposure, high-energy laser settings with conventional settings, using a 532 nm, frequ...
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Article
Is measurement of blood pressure worthwhile in the diabetic eye clinic?
The UK Prospective Diabetic Study has confirmed the importance of blood pressure (BP) as a major risk factor for diabetic retinopathy (DR). We wanted to investigate whether measuring the BP in the diabetic eye...
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Article
Does cardiovascular therapy affect the onset and recurrence of preretinal and vitreous haemorrhage in diabetic eye disease?
Aims To review the role of cardiovascular disease and therapy in the onset and recurrence of preretinal/vitreous haemorrhage in diabetic patients.
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Article
The platelet glycoprotein Ia/IIa gene polymorphism C807T/G873A: a novel risk factor for retinal vein occlusion
Retinal vein occlusion (RVO) is associated with hyperhomocysteinaemia and the antiphospholipid syndrome—disorders known to contribute to both arterial and venous thrombosis. In both of these conditions and RVO...
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Article
Medical treatment of diabetic retinopathy
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Article
The role of serum lipids in exudative diabetic maculopathy: is there a place for lipid lowering therapy?
Diabetic maculopathy is a common complication of diabetes mellitus, characterised by macular oedema and frequently accompanied by lipid exudation. It is the major cause of loss of vision from diabetic retinopa...
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Article
Nine year follow-up study of morbidity and mortality in retinal vein occlusion
Purpose The aim of this study was to conduct a detailed retrospective follow-up of a large cohort of patients with retinal vein occlusion (RVO), examining morbidity and mortality, to investigate a possible relati...
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Article
Plasma total homocysteine and retinal vascular disease
Purpose Hyperhomocysteinaemia has been linked to macrovascular disease. Our aim was to investigate whether there is a relationship between fasting plasma total homocysteine levels and retinal vascular disease. Me...
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Article
The National Diabetic Retinopathy Laser Treatment Audit: implications for clinical practice in 1998
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Article
Diabetic eye disease: A natural history study
In previous studies on diabetic retinopathy it has not been possible to relate risk factors to reduced vision because of the influence of vision-preserving treatment. Demographic data, cardiovascular risk fact...
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Article
Sex hormone preparations and retinal vein occlusion
Retinal vein occlusion (RVO) is most commonly seen in middle-aged or older patients and is associated with underlying cardiovascular risk factors. It is much less common in younger patients. Use of the oral co...
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Article
Medical cardiovascular treatment trials: Relevant to medical ophthalmology in 1997?
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Article
The acute and long-term ocular effects of accelerated hypertension: A clinical and electrophysiological study
Thirty-four patients with accelerated hypertension were clinically examined. The visual evoked potential (VEP) and electroretinogram (ERG) were recorded: acutely in 12 patients, being repeated in 7 patients up...
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Article
Fibrinogen, cholesterol and smoking as risk factors for non-arteritic anterior ischaemic optic neuropathy
Non-arteritic anterior ischaemic optic neuropathy (AION) is thought to be due to occlusion of the posterior ciliary circulation. Raised lipid and fibrino-gen concentrations are recognised risk factors for vess...
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Article
Are there medical conditions specifically underlying the development of rubeosis in central retinal vein occlusion?
Two hundred and thirty five patients with central retinal vein occlusion (mean age 64.9 years, 95% CI (63.3, 66.5) years), comprising 221 white Europeans, 10 Asians and 4 West Indians) were studied over a 7 ye...