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Article
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts
A mouse model shows that osteoblast activating β-catenin mutations alone are sufficient to initiate the development of acute myeloid leukaemia acting through increased Notch signalling.
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Article
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
Deletions on chromososme 5q are associated with myelodysplastic lesions. The genes responsible have largely remained elusive. But use of an RNA interference-based approach that can identify haploinsufficient t...