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    Article

    Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

    A mouse model shows that osteoblast activating β-catenin mutations alone are sufficient to initiate the development of acute myeloid leukaemia acting through increased Notch signalling.

    Aruna Kode, John S. Manavalan, Ioanna Mosialou, Govind Bhagat, Chozha V. Rathinam… in Nature (2014)

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    Article

    Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

    Deletions on chromososme 5q are associated with myelodysplastic lesions. The genes responsible have largely remained elusive. But use of an RNA interference-based approach that can identify haploinsufficient t...

    Benjamin L. Ebert, Jennifer Pretz, Jocelyn Bosco, Cindy Y. Chang, Pablo Tamayo… in Nature (2008)