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Low frequency magnetic field assisted production of acidic protease by Aspergillus niger
Acid protease is widely used in industries such as food processing and feed additives. In the study, low frequency magnetic field (LF-MF) as an aid enhances acid protease production by Aspergillus niger (A. niger
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Article
Open AccessTREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53
Efferocytosis and metabolic reprogramming of macrophages play crucial roles in myocardial infarction (MI) repair. TREM2 has been proven to participate in phagocytosis and metabolism, but how it modulates myoca...
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Article
Open AccessChimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside
Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have demonstrated significant success in certain hematologic malignancies,...
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Article
Open AccessAdipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice
Lipodystrophy-associated metabolic disorders caused by Seipin deficiency lead to not only severe lipodystrophy but also neurological disorders. However, the underlying mechanism of Seipin deficiency-induced ne...
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Article
Static Magnetic Fields Promote Generation of Muscle Lineage Cells from Pluripotent Stem Cells and Myoblasts
Static magnetic fields (SMFs) exhibit numerous biological effects and regulate the proliferation and differentiation of several adult stem cells. However, the role of SMFs in the self-renewal maintenance and d...
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Article
Lactoferrin, a Great Wall of host-defence?
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Effects of dietary supplementation of bovine lactoferrin on growth performance, immune function and intestinal health in weaning piglets
Weaning is a crucial period in the pig’s life cycle, which is frequently followed by gastrointestinal (GI) infections, diarrhea and even death. This study focused on the impact of bovine lactoferrin (bLF) supp...
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Article
Open AccessLong non-coding RNA KCND1 protects hearts from hypertrophy by targeting YBX1
Cardiac hypertrophy is a common structural remodeling in many cardiovascular diseases. Recently, long non-coding RNAs (LncRNAs) were found to be involved in the physiological and pathological processes of card...
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Article
Open AccessRibosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway
Abnormal expression of ribosomal proteins has an important regulatory effect on the progression of cancer. RPL5 is involved in the progression of various malignancies, however, the role of RPL5 in colon cancer...
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Article
Open AccessSpontaneous necroptosis and autoinflammation are blocked by an inhibitory phosphorylation on MLKL during neonatal development
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Article
Activation of Autophagy Ameliorates Age-Related Neurogenesis Decline and Neurodysfunction in Adult Mice
Adult neurogenesis is the ongoing generation of functional new neurons from neural progenitor cells (NPCs) in the mammalian brain. However, this process declines with aging, which is implicated in the recessio...
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Article
Open AccessOverexpression of FES might inhibit cell proliferation, migration, and invasion of osteosarcoma cells
This study aimed to screen osteosarcoma (OS) prognosis relevant genes for methylation dysregulation, and the functional mechanisms of FES overexpression in OS cells were investigated.
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Article
The complete mitochondrial genome of Cobitis macrostigma (Cypriniformes: Cobitidae: Cobitinae) and a phylogenetic implication for its closely related species
Cobitis macrostigma, a small-sized benthic fish species, is an endemic species distributing in the middle and lower reaches of the Yangtze River. In this study, the complete mitochondrial genome of C. macrostigma
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Article
Open AccessLong non-coding RNA ANRIL-mediated inflammation response is involved in protective effect of rhein in uric acid nephropathy rats
The aim of this study was to investigate the role of long non-coding RNAs (LncRNAs) antisense non-coding RNA in the INK4 locus (ANRIL) in anti-inflammation of rhein in uric acid nephropathy (UAN) rats.
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Article
Open AccessArchitecture of SWI/SNF chromatin remodeling complex
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A review of the design and modification of lactoferricins and their derivatives
Lactoferricin (Lfcin), a multifunction short peptide with a length of 25 residues, is derived from the whey protein lactoferrin by acidic pepsin hydrolysis. It has potent nutritional enhancement, antimicrobial...
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Article
Resveratrol Inhibits Diabetic-Induced Müller Cells Apoptosis through MicroRNA-29b/Specificity Protein 1 Pathway
The aim of this study was to evaluate the anti-apoptosis effects of resveratrol (RSV) on diabetic rats retinal Müller cells in vivo and in vitro and to further investigate the roles of microRNA-29b (miR-29b)/s...
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Article
Resveratrol Prevents Retinal Dysfunction by Regulating Glutamate Transporters, Glutamine Synthetase Expression and Activity in Diabetic Retina
This study investigated the effects of resveratrol (RSV) on retinal functions, glutamate transporters (GLAST) and glutamine synthetase (GS) expression in diabetic rats retina, and on glutamate uptake, GS activ...
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Article
Open AccessStructure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2
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Article
Plasma membrane H+-ATPase is involved in methyl jasmonate-induced root hair formation in lettuce (Lactuca sativa L.) seedlings
Our results show that methyl jasmonate induces plasma ...