15 Result(s)
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Article
Low frequency magnetic field assisted production of acidic protease by Aspergillus niger
Acid protease is widely used in industries such as food processing and feed additives. In the study, low frequency magnetic field (LF-MF) as an aid enhances acid protease production by Aspergillus niger (A. niger
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Article
Open AccessTREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53
Efferocytosis and metabolic reprogramming of macrophages play crucial roles in myocardial infarction (MI) repair. TREM2 has been proven to participate in phagocytosis and metabolism, but how it modulates myoca...
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Article
Recent advances in targeted protein degraders as potential therapeutic agents
Targeted protein degradation (TPD) technology has gradually become widespread in the past 20 years, which greatly boosts the development of disease treatment. Contrary to small inhibitors that act on protein k...
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Article
Open AccessChimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside
Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have demonstrated significant success in certain hematologic malignancies,...
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Article
Lactoferrin, a Great Wall of host-defence?
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Article
Effects of dietary supplementation of bovine lactoferrin on growth performance, immune function and intestinal health in weaning piglets
Weaning is a crucial period in the pig’s life cycle, which is frequently followed by gastrointestinal (GI) infections, diarrhea and even death. This study focused on the impact of bovine lactoferrin (bLF) supp...
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Article
Open AccessLong non-coding RNA KCND1 protects hearts from hypertrophy by targeting YBX1
Cardiac hypertrophy is a common structural remodeling in many cardiovascular diseases. Recently, long non-coding RNAs (LncRNAs) were found to be involved in the physiological and pathological processes of card...
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Article
A superior allele of the wheat gene TaGL3.3-5B, selected in the breeding process, contributes to seed size and weight
A superior allele of wheat gene TaGL3.3-5B was identified and could be used in marker-assisted breeding in wheat.
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Article
Reduced thiamine binding is a novel mechanism for TPK deficiency disorder
Thiamine pyrophosphokinase (TPK) converts thiamine (vitamin B1) into thiamine pyrophosphate (TPP), an essential cofactor for many important enzymes. TPK1 mutations lead to a rare disorder: episodic encephalopathy...
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Article
Open AccessArchitecture of SWI/SNF chromatin remodeling complex
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Article
A review of the design and modification of lactoferricins and their derivatives
Lactoferricin (Lfcin), a multifunction short peptide with a length of 25 residues, is derived from the whey protein lactoferrin by acidic pepsin hydrolysis. It has potent nutritional enhancement, antimicrobial...
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Article
Open AccessStructure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2
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Article
Taurine prevents high glucose-induced angiopoietin-2/tie-2 system alterations and apoptosis in retinal microvascular pericytes
Previously, we confirmed that taurine prevented diabetes-induced apoptosis in retinal glial cells via its anti-oxidation and anti-glutamate excitotoxicity mechanisms. The aim of this study is to investigate th...
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Article
Nα-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain
Acetylation of the Sir3 N terminus is important for transcriptional silencing in budding yeast and is thought to promote binding of the Sir3 BAH domain to the nucleosome. Structural and biochemical analyses no...
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Article
Structure of the variant histone H3.3–H4 heterodimer in complex with its chaperone DAXX
The histone variant H3.3 is deposited onto pericentric and telomeric heterochromatin by the histone chaperone DAXX. How DAXX selectively recognizes H3.3 over the canonical H3.1 is now revealed by the crystal s...
