18 Result(s)
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Mi-Young Son
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Open AccessThe secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation
Akkermansia muciniphila has received great attention because of its beneficial roles in gut health by regulating gut immunity, promoting intestinal epithelial development, and improving barrier integrity. However...
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Open AccessChemically-defined and scalable culture system for intestinal stem cells derived from human intestinal organoids
Three-dimensional human intestinal organoids (hIO) are widely used as a platform for biological and biomedical research. However, reproducibility and challenges for large-scale expansion limit their applicabil...
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Open AccessEpigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis
Epigenetic alterations, especially histone methylation, are key factors in cell migration and invasion in cancer metastasis. However, in lung cancer metastasis, the mechanism by which histone methylation regul...
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Open AccessParticulate matter promotes cancer metastasis through increased HBEGF expression in macrophages
Although many cohort studies have reported that long-term exposure to particulate matter (PM) can cause lung cancer, the molecular mechanisms underlying the PM-induced increase in cancer metastasis remain uncl...
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Open AccessCorrection to: Characterization of terminal-ileal and colonic Crohn’s disease in treatment-naïve paediatric patients based on transcriptomic profile using logistic regression
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Open AccessDevelopment of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
Human pluripotent stem cell (hPSC)-derived organoids and cells have similar characteristics to human organs and tissues. Thus, in vitro human organoids and cells serve as a superior alternative to conventional...
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Open AccessCharacterization of terminal-ileal and colonic Crohn’s disease in treatment-naïve paediatric patients based on transcriptomic profile using logistic regression
Inflammatory bowel disease (IBD) is a chronic and idiopathic inflammatory disorder of the gastrointestinal tract and comprises ulcerative colitis (UC) and Crohn’s disease (CD). Crohn’s disease can affect any p...
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Open AccessBacterial type III effector protein HopQ inhibits melanoma motility through autophagic degradation of vimentin
Malignant melanoma is a fatal disease that rapidly spreads to the whole body. Treatments have limited efficiency owing to drug resistance and various side effects. Pseudomonas syringae pv. tomato (Pto) is a model...
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Open AccessEfficient exogenous DNA-free reprogramming with suicide gene vectors
Reprogramming with episomal vectors is an easy, safe, and cost-effective method to generate exogenous DNA-free (exogene-free) induced pluripotent stem cells (iPSCs). However, the genomic integration of exogene...
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Open AccessHuman three-dimensional in vitro model of hepatic zonation to predict zonal hepatotoxicity
Various hepatic models mimicking liver lobules have been investigated to evaluate the potential hepatotoxic effects of chemicals and drugs, but in vitro hepatic models of zonal hepatotoxicity have not yet been...
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Open AccessModelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells
Cardiac fibrosis is the most common pathway of many cardiac diseases. To date, there has been no suitable in vitro cardiac fibrosis model that could sufficiently mimic the complex environment of the human hear...
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Open AccessInterleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
Human pluripotent stem cell (hPSC)-derived intestinal organoids (hIOs) form 3D structures organized into crypt and villus domains, making them an excellent in vitro model system for studying human intestinal d...
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Comparative in silico profiling of epigenetic modifiers in human tissues
The technology of tissue differentiation from human pluripotent stem cells has attracted attention as a useful resource for regenerative medicine, disease modeling and drug development. Recent studies have sug...
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Open AccessGeneration and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease
Autoimmune diseases (AIDs), a heterogeneous group of immune-mediated disorders, are a major and growing health problem. Although AIDs are currently treated primarily with anti-inflammatory and immunosuppressiv...
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Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes
Stalling of replication forks in sequences that have non-allelic repeats can lead to genomic rearrangements; here two pathways consistent with homologous recombination and error-free post-replication repair fu...
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Expression of p25, an aberrant cyclin-dependent kinase 5 activator, stimulates basal secretion in PC12 cells
Although alterations in the functions of neurotransmitter systems have been implicated in the pathology of Alzheimer’s disease (AD), the mechanisms that give rise to these alterations are not well understood. ...
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Open AccessNotch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells
Studies have provided important findings about the roles of Notch signaling in neural development. Unfortunately, however, most of these studies have investigated the neural stem cells (NSCs) of mice or other ...
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Isolation and Characterization of Ornithine Decarboxylase Gene from Flounder (Paralichthys olivaceus)
Ornithine decarboxylase (ODC) is a homodimeric enzyme dependent on pyridoxal 5’-phosphate. We identified a complementary DNA clone corresponding to ODC from the brain of adult flounder (Paralichthys olivaceus). T...
