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  1. No Access

    Article

    Network-based assessment of HDAC6 activity predicts preclinical and clinical responses to the HDAC6 inhibitor ricolinostat in breast cancer

    Inhibiting individual histone deacetylase (HDAC) is emerging as well-tolerated anticancer strategy compared with pan-HDAC inhibitors. Through preclinical studies, we demonstrated that the sensitivity to the le...

    Tizita Z. Zeleke, Qingfei Pan, Codruta Chiuzan, Maika Onishi, Yuxin Li… in Nature Cancer (2023)

  2. Article

    Open Access

    PET2 response associated with survival in newly diagnosed diffuse large B-cell lymphoma: results of two independent prospective cohorts

    Studies evaluating Positron Emission Tomography scan after 2 cycles of chemotherapy (PET2) in newly diagnosed diffuse large B cell lymphoma (DLBCL) are heterogeneous in patient characteristics, treatments and ...

    Sanjal H. Desai, Levi Pederson, Betsy LaPlant, Raphael Mwangi… in Blood Cancer Journal (2022)

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  3. No Access

    Article

    Phase II study of propranolol feasibility with neoadjuvant chemotherapy in patients with newly diagnosed breast cancer

    Propranolol regulates angiogenesis in pre-clinical models and reduces distant breast cancer (BC) metastases in observational studies. We assessed the feasibility of combining propranolol with neoadjuvant chemo...

    Madeleine B. Hopson, Shing Lee, Melissa Accordino… in Breast Cancer Research and Treatment (2021)

  4. Article

    Open Access

    31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

    Andreas Lundqvist, Vincent van Hoef, **aonan Zhang… in Journal for ImmunoTherapy of Cancer (2016)

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  5. Article

    Open Access

    31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

    Casey Ager, Matthew Reilley, Courtney Nicholas… in Journal for ImmunoTherapy of Cancer (2016)

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  6. Article

    Open Access

    Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer

    The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with current...

    Qing-Bai She, Sofia K. Gruvberger-Saal, Matthew Maurer, Yilun Chen… in BMC Cancer (2016)

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  7. No Access

    Article

    Phase I/II study of pilaralisib (SAR245408) in combination with trastuzumab or trastuzumab plus paclitaxel in trastuzumab-refractory HER2-positive metastatic breast cancer

    This phase I/II dose-escalation study investigated the maximum tolerated dose (MTD), safety, pharmacokinetics, and efficacy of the pan-class I phosphoinositide 3-kinase inhibitor pilaralisib in combination wi...

    Sara Tolaney, Howard Burris, Elaina Gartner… in Breast Cancer Research and Treatment (2015)

  8. No Access

    Article

    Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer

    Many women with hormone receptor-positive breast cancer discontinue effective aromatase inhibitor (AI) treatment due to joint symptoms.

    Heather Greenlee, Katherine D. Crew, Theresa Shao… in Supportive Care in Cancer (2013)

  9. No Access

    Article

    Randomized controlled trial of a clinic-based survivorship intervention following adjuvant therapy in breast cancer survivors

    In 2006, the IOM released a report citing the importance of “survivorship plans” to improve quality of life and care coordination for cancer survivors, but little has been done to evaluate their efficacy. Wome...

    Dawn L. Hershman, Heather Greenlee, Danielle Awad… in Breast Cancer Research and Treatment (2013)

  10. No Access

    Article

    Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair

    Basal-like breast cancer (BBC) is a subtype of breast cancer with poor prognosis1,2,3. Inherited mutations of BRCA1, a cancer susceptibility gene involved in double-strand DNA break (DSB) repair, lead to breast c...

    Lao H Saal, Sofia K Gruvberger-Saal, Camilla Persson, Kristina Lövgren… in Nature Genetics (2008)

  11. No Access

    Article

    Buttons and cards and fields, oh my

    Arthur Hochman, Matthew Maurer, Douglas Roebuck in TechTrends (1993)