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Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women

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  1. Article

    Open Access

    Breast ductal lavage for biomarker assessment in high risk women: rationale, design and methodology of a randomized phase II clinical trial with nimesulide, simvastatin and placebo

    Despite positive results from large phase III clinical trials proved that it is possible to prevent estrogen-responsive breast cancers with selective estrogen receptor modulators and aromatase inhibitors, no s...

    Matteo Lazzeroni, Aliana Guerrieri-Gonzaga, Davide Serrano… in BMC Cancer (2012)

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  2. Article

    Open Access

    A randomized phase II presurgical trial of weekly low-dose tamoxifen versus raloxifene versus placebo in premenopausal women with estrogen receptor-positive breast cancer

    We previously demonstrated that 1 or 5 mg per day of tamoxifen (T) given for four weeks before surgery reduces Ki-67 in breast cancer (BC) patients to the same extent as the standard 20 mg/d. Given the long ha...

    Davide Serrano, Matteo Lazzeroni, Sara Gandini, Debora Macis… in Breast Cancer Research (2013)

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  3. Article

    Open Access

    Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial

    Treatment of diabetics with metformin is associated with decreased breast cancer risk in observational studies, but it remains unclear if this drug has clinical antineoplastic activity. In a recent presurgical...

    Andrea DeCensi, Matteo Puntoni, Sara Gandini… in Breast Cancer Research and Treatment (2014)

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