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  1. No Access

    Article

    Sevoflurane induces cardioprotection through reactive oxygen species-mediated upregulation of autophagy in isolated guinea pig hearts

    Sevoflurane increases reactive oxygen species (ROS), which mediate cardioprotection against myocardial ischemia–reperfusion injury. Emerging evidence suggests that autophagy is involved in cardioprotection. We...

    Mayumi Shiomi, Masami Miyamae, Genzou Takemura, Kazuhiro Kaneda… in Journal of Anesthesia (2014)

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    Article

    Combination of necroptosis and apoptosis inhibition enhances cardioprotection against myocardial ischemia–reperfusion injury

    Necroptosis has been proposed as a mode of cell death that is a caspase-independent programmed necrosis. We investigated whether necroptosis is involved in myocardial ischemia–reperfusion injury in isolated gu...

    Shizuka Koshinuma, Masami Miyamae, Kazuhiro Kaneda… in Journal of Anesthesia (2014)

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    Article

    Sevoflurane postconditioning prevents activation of caspase 3 and 9 through antiapoptotic signaling after myocardial ischemia–reperfusion

    Volatile anesthetic postconditioning reduces apoptosis through antiapoptotic signaling. Whether sevoflurane postconditioning prevents activation of caspase 9 and 3, which are implicated in the initiation and e...

    Yoshitaka Inamura, Masami Miyamae, Shingo Sugioka, Naochika Domae… in Journal of Anesthesia (2010)