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Open AccessJuvenile dermatomyositis: association between nail fold capillary end row loop– area under the curve– and disease damage indicators
Juvenile Dermatomyositis (JDM) is a rare autoimmune disease characterized by skin and muscle inflammation. The loss of nail fold capillary end row loops (ERL) is evidence of small vessel involvement in JDM. Th...
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Article
Open AccessNailfold capillary density in 140 untreated children with juvenile dermatomyositis: an indicator of disease activity
We lack a reliable indicator of disease activity in Juvenile Dermatomyositis (JDM), a rare disease. The goal of this study is to identify the association of nailfold capillary End Row Loop (ERL) loss with dise...
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Article
Open AccessRituximab-associated Hypogammaglobulinemia in pediatric patients with autoimmune diseases
Despite the increased use of rituximab in treating pediatric patients with autoimmune diseases in the last decade, there are limited data on rituximab safety in those subjects who have a develo** immune syst...
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Article
Open AccessPilot study comparing the childhood arthritis and rheumatology research alliance consensus treatment plans for induction therapy of juvenile proliferative lupus nephritis
To reduce treatment variability and facilitate comparative effectiveness studies, the Childhood Arthritis and Rheumatology Research Alliance (CARRA) published consensus treatment plans (CTPs) including one for...
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Article
Open AccessUrine S100 proteins as potential biomarkers of lupus nephritis activity
Improved, noninvasive biomarkers are needed to accurately detect lupus nephritis (LN) activity. The purpose of this study was to evaluate five S100 proteins (S100A4, S100A6, S100A8/9, and S100A12) in both seru...
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Article
Open AccessAn Update on Treatment and Management of Pediatric Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disorder in which 20 % of patients are diagnosed in childhood. Childhood-onset SLE is associated with higher morbidity and mortality than ...
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Article
Neonatal Lupus: What We Have Learned and Current Approaches to Care
Neonatal lupus results from the passive transfer of autoantibodies; however, this transfer is not sufficient to cause disease. This article reviews clinical presentation with a focus on autoimmune-mediated con...
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Article
Open AccessFunctional neuronal network activity differs with cognitive dysfunction in childhood-onset systemic lupus erythematosus
Neuropsychiatric manifestations are common in childhood-onset systemic lupus erythematosus (cSLE) and often include neurocognitive dysfunction (NCD). Functional magnetic resonance imaging (fMRI) can measure br...
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Open AccessDevelo** consensus treatment plans for proliferative lupus nephritis in childhood-onset systemic lupus erythematous
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Article
Open AccessAsymptomatic intracardiac mass in a 14-year-old girl with granulomatosis with polyangiitis: Case report
Granulomatosis with polyangiitis (GPA; Wegener’s granulomatosis) is a systemic necrotizing vasculitis of unknown etiology that commonly involves the upper airways, lungs, and kidneys. Cardiac involvement with ...
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Article
Pediatric SLE—towards a comprehensive management plan
In this Review, the authors describe the marked differences in clinical presentation, prognosis, disease assessment and treatment options that exist between pediatric and adult-onset systemic lupus erythematos...