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Article
Open AccessFractal analysis of extracellular matrix for observer-independent quantification of intestinal fibrosis in Crohn’s disease
Prevention of intestinal fibrosis remains an unresolved problem in the treatment of Crohn’s disease (CD), as specific antifibrotic therapies are not yet available. Appropriate analysis of fibrosis severity is ...
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Article
Open AccessA nationwide population-based study on the clinical and economic burden of anastomotic leakage in colorectal surgery
Anastomotic leakage (AL) is one of the most dreaded complications in colorectal surgery. In 2013, the International Classification of Diseases code K91.83 for AL was introduced in Germany, allowing nationwide ...
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Article
Open AccessCrohn’s disease: a population-based study of surgery in the age of biological therapy
Despite primary conservative therapy for Crohn’s disease, a considerable proportion of patients ultimately needs to undergo surgery. Presumably, due to the increased use of biologics, the number of surgeries m...
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Article
Androgens sensitise mice to glucocorticoid-induced insulin resistance and fat accumulation
Chronic glucocorticoid therapy causes insulin resistance, dyslipidaemia, abnormal fat accumulation, loss of muscle mass and osteoporosis. Here we describe a hitherto unknown sexual dimorphism in the metabolic ...