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  1. Article

    Open Access

    Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

    In melanoma, therapies with inhibitors to oncogenic BRAFV600E are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of ...

    Rajasekharan Somasundaram, Gao Zhang, Mizuho Fukunaga-Kalabis… in Nature Communications (2017)

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  2. Article

    Open Access

    An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides

    The histone deacetylase HDAC3 is a critical mediator of hepatic lipid metabolism, and liver-specific deletion of HDAC3 leads to fatty liver. To elucidate the underlying mechanism, here we report a method of cr...

    Sean M. Armour, Jarrett R. Remsberg, Manashree Damle… in Nature Communications (2017)

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  3. No Access

    Article

    Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion

    Genetic deletion of HDAC3, a circadian epigenome regulator, specifically in skeletal muscle alters amino acid metabolism, leading to increased muscle endurance but at the cost of whole-body insulin resistance.

    Sungguan Hong, Wenjun Zhou, Bin Fang, Wenyun Lu, Emanuele Loro… in Nature Medicine (2017)