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Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis
Immunization of transgenic mouse models of Alzheimer disease using amyloid-β peptide (Aβ) reduces both the Alzheimer disease–like neuropathology and the spatial memory impairments of these mice. However, a the...
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Article
Open AccessPropagation of the 2001–2002 silent earthquake and interplate coupling in the Oaxaca subduction zone, Mexico
The aseismic slow slip event of 2001–2002 in Guerrero, Mexico, with an equivalent magnitude MW ~ 7.5, is the largest silent earthquake (SQ) among many recently recorded by GPS in different subduction zones (i.e. ...
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Article
The importance of digital elevation model resolution on granular flow simulations: a test case for Colima volcano using TITAN2D computational routine
The mobility of gravity-driven granular flows such as debris flows or pyroclastic density currents are extremely sensitive to topographic changes, such as break in slopes, obstacles, or ravine deviations. In h...
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Article
Open AccessNumerical modeling of subduction and evaluation of Philippine Sea Plate tectonic history along the Nankai Trough
The subduction of the Philippine Sea (PHS) plate along the Nankai Trough in in southwest Japan is a relatively recent process compared with subduction along the Japan Trench in northeast Japan. However, the te...
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Article
Open AccessThe geodynamic origin of Los Humeros volcanic field in Mexico: insights from numerical simulations
Compared to normal arc-related volcanic eruptions, the formation of a volcanic caldera is a relatively atypical event. During caldera formation a series of large volumes of magma are erupted, reducing the stru...
