233 Result(s)
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Article
M. **gliang
Cell Biology
Stem Cells
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Open AccessAn activity-specificity trade-off encoded in human transcription factors
Transcription factors (TFs) control specificity and activity of gene transcription, but whether a relationship between these two features exists is unclear. Here we provide evidence for an evolutionary trade-o...
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Human-in-the-loop avatar chatbot shows promise in supporting hematopoietic stem cell transplantation patients
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Open AccessStandardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions
There is a significant demand for intermediate-scale bioreactors in academic and industrial institutions to produce cells for various applications in drug screening and/or cell therapy. However, the applicatio...
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Open AccessClathrin mediates membrane fission and budding by constricting membrane pores
Membrane budding, which underlies fundamental processes like endocytosis, intracellular trafficking, and viral infection, is thought to involve membrane coat-forming proteins, including the most observed clath...
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SenNet recommendations for detecting senescent cells in different tissues
Once considered a tissue culture-specific phenomenon, cellular senescence has now been linked to various biological processes with both beneficial and detrimental roles in humans, rodents and other species. Mu...
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Open AccessTargeting miR-181a/b in retinitis pigmentosa: implications for disease progression and therapy
Retinitis pigmentosa (RP) is a genetically heterogeneous group of degenerative disorders causing progressive vision loss due to photoreceptor death. RP affects other retinal cells, including the retinal pigmen...
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Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)
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Open AccessStructural, angiogenic, and immune responses influencing myocardial regeneration: a glimpse into the crucible
Complete cardiac regeneration remains an elusive therapeutic goal. Although much attention has been focused on cardiomyocyte proliferation, especially in neonatal mammals, recent investigations have unearthed ...
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Open AccessValidation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation
The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning ...
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Open AccessMyeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration
Regulation of myeloid cell activity is critical for successful myelin regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis (MS). Here, we show aromatic alpha-keto acids (AKAs) gen...
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Challenges and opportunities in macromolecular structure determination
Embedded within the complexity of biological systems lies a formidable task: deciphering the intricate architecture of macromolecules. In this Viewpoint, a panel of experts discuss the key challenges and oppor...
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Vitamin B12 produced by gut bacteria modulates cholinergic signalling
A growing body of evidence indicates that gut microbiota influence brain function and behaviour. However, the molecular basis of how gut bacteria modulate host nervous system function is largely unknown. Here ...
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Open AccessProstate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Lineage transitions are a central feature of prostate development, tumourigenesis and treatment resistance. While epigenetic changes are well known to drive prostate lineage transitions, it remains unclear how...
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No impact of CD34+ cell dose on outcome among children undergoing autologous hematopoietic stem cell transplant for high-risk neuroblastoma
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Open AccessInduced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
Human mitochondrial DNA mutations are associated with common to rare mitochondrial disorders, which are multisystemic with complex clinical pathologies. The pathologies of these diseases are poorly understood ...
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Hem25p is required for mitochondrial IPP transport in fungi
Coenzyme Q (CoQ, ubiquinone) is an essential cellular cofactor composed of a redox-active quinone head group and a long hydrophobic polyisoprene tail. How mitochondria access cytosolic isoprenoids for CoQ bios...
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Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis
Brain metastases represent an important clinical problem for patients with small-cell lung cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain poorly understood. Here, using intra...
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Open AccessHuman retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming
In optic neuropathies, including glaucoma, retinal ganglion cells (RGCs) die. Cell transplantation and endogenous regeneration offer strategies for retinal repair, however, developmental programs required for ...
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Open AccessTransplanted ENSCs form functional connections with intestinal smooth muscle and restore colonic motility in nNOS-deficient mice
Enteric neuropathies, which result from abnormalities of the enteric nervous system, are associated with significant morbidity and high health-care costs, but current treatments are unsatisfactory. Cell-based ...
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Open AccessCAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma
MAD2 is a spindle assembly checkpoint protein that participates in the formation of mitotic checkpoint complex, which blocks mitotic progression. RNF8, an established DNA damage response protein, has been impl...
