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  1. Article

    Open Access

    The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology

    Central nervous system (CNS)-resident cells such as microglia, oligodendrocytes and astrocytes are gaining increasing attention in respect to their contribution to CNS pathologies including multiple sclerosis ...

    Mathias Linnerbauer, Lena Lößlein, Oliver Vandrey, Anne Peter… in Nature Immunology (2024)

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  2. Article

    Open Access

    B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4

    Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target antigen1. The immunopathology in neuromyelitis optica is largely driv...

    Ali Maisam Afzali, Lucy Nirschl, Christopher Sie, Monika Pfaller, Oleksii Ulianov… in Nature (2024)

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  3. Article

    Open Access

    PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation

    Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disorder of the central nervous system (CNS). Current therapies mainly target inflammatory processes during acute stages, but effective treatments f...

    Mathias Linnerbauer, Tobias Beyer, Lucy Nirschl, Daniel Farrenkopf… in Nature Communications (2023)

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