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  1. No Access

    Article

    Blockade of PD-1 and TIM-3 Ameliorates CD8+ T Cell Exhaustion in a Mouse Model of Chronic Myeloid Leukemia

    The immune system plays a pivotal role in controlling chronic myeloid leukemia (CML). CD8+ T cell exhaustion results in reduced effectiveness of T cell-mediated immunity, thereby contributing to disease progressi...

    Ting **, Fei Gao, Li Wang in Cell Biochemistry and Biophysics (2024)

  2. No Access

    Article

    Hinesol attenuates DSS-induced ulcerative colitis through the suppression of Src-mediated NF-κB and chemokine signaling pathway

    As a common inflammatory bowel disease, ulcerative colitis (UC) is featured with inflammation, oxidative damage, and the impairment of intestinal mucosal barrier, which bring threat to patients’ quality of liv...

    Yun-xia Li, **zhong Liu, Fang Li in Cell Biochemistry and Biophysics (2024)

  3. No Access

    Article

    Aucubin Alleviates Chronic Obstructive Pulmonary Disease by Activating Nrf2/HO-1 Signaling Pathway

    Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease with high death rates. Aucubin is an iridoid glycoside extracted from Eucommia ulmoides with antioxidative and anti-inflammator...

    Ting Liu, Yang Li, Nan Hu in Cell Biochemistry and Biophysics (2024)

  4. No Access

    Article

    Smart Dressings and Their Applications in Chronic Wound Management

    During chronic wound healing, the inflammatory phase can endure for extended periods, heavily impeding or halting the process. Regular inspections and dressing changes are crucial. Modern dressings like hydrog...

    **aodong Li, **aodong Xue, Peilin **e in Cell Biochemistry and Biophysics (2024)

  5. No Access

    Article

    TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer

    Triple-negative breast cancer (TNBC) is characterized by a grim prognosis and numerous challenges. The objective of our study was to examine the role of thymidylate synthase (TYMS) in TNBC and its impact on fe...

    Lin Wang, Zheyi Wu, Yanyan Wang, Chunchun Chen… in Cell Biochemistry and Biophysics (2024)

  6. No Access

    Article

    Unraveling the Drug Response Heterogeneity with Single-Cell Vibrational Phenomics

    Drug responses heterogeneity is often highlighted to justify the need for precision medicine. However, due to the highly complex nature of cell phenotypes in many diseases, one of key challenges is how to obta...

    Yue Wang, Yadi Wang, Junhong Lü, Xueling Li in Cell Biochemistry and Biophysics (2024)

  7. No Access

    Article

    Influence of SphK1 on Inflammatory Responses in Lipopolysaccharide-Challenged RAW 264.7 Cells

    Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious respiratory disorders caused by a variety of intrapulmonary and extrapulmonary factors. Their incidence is increasing year by ...

    Chao-shun Wei, Lin-li Song, Zi-xi Peng, **ao-Li Wang in Cell Biochemistry and Biophysics (2024)

  8. No Access

    Article

    Isoquercitrin alleviates OGD/R-induced oxidative stress and impaired mitochondrial biogenesis in SH-SY5Y cells via the NRF1/TFAM pathway

    Isoquercitrin (ISO) is a traditional Chinese medicine extract, that has been found to possess potent neuroprotective properties. However, its precise role in the context of ischemic stroke (IS) remains to be f...

    ** Li, Yujie Li, KeRui Wang, Sike Qi, Zherui Zhang… in Cell Biochemistry and Biophysics (2024)

  9. No Access

    Article

    MiRNA-133a-3p Attenuates Renal Tubular Epithelial Cell Injury via Targeting MALM1 and Suppressing the Notch Signaling Pathway in Diabetic Nephropathy

    Diabetic nephropathy (DN) is a serious microvascular complication of diabetes characterized by structural and functional changes of kidneys. Human renal tubular epithelial (HK-2) cells are important for kidney...

    Yuting Li, Peng Tan, Qianpan Liu, Man Liu, Yue Wang… in Cell Biochemistry and Biophysics (2024)

  10. No Access

    Article

    Inhibition of ASAP1 Modulates the Tumor Immune Microenvironment and Suppresses Lung Cancer Metastasis via the p-STAT3 Signaling Pathway

    ADP ribosylation factor guanylate kinase 1 (ASAP1), a key protein regulating cell migration and invasion, has attracted extensive attention in oncological research in recent years. This study aims to explore t...

    Hongye Zhao, Yongcun Liu, Yunfan Wu, **gge Cheng… in Cell Biochemistry and Biophysics (2024)

  11. No Access

    Article

    TROP2 promotes the proliferation of triple-negative breast cancer cells via calcium ion-dependent ER stress signaling pathway

    Objective: To explore the molecular mechanisms of tumor-associated calcium signal transduction factor 2 (TROP2) affecting the occurrence and development of triple-negative breast cancer (TNBC). Methods: The TC...

    Ning Li, Jianzhong Xu, ** Yan, Qing Liu, Mingqi Zhang in Cell Biochemistry and Biophysics (2024)

  12. No Access

    Article

    Unveiling the Pharmacological Role of Human Deubiquitinating Enzymes in Temozolomide Response of Glioblastoma Cells

    Temozolomide (TMZ) stands as the primary chemotherapeutic drug utilized in clinical glioma treatment, particularly for high-grade glioblastoma (GBM). However, the emergence of TMZ resistance in GBM poses a sig...

    Chunguang Yang, Yifei Li, Qifan Wu, Jiayi Tang… in Cell Biochemistry and Biophysics (2024)

  13. No Access

    Article

    Targeting the Ferroptosis and Endoplasmic Reticulum Stress Signaling Pathways by CBX7 in Myocardial Ischemia/reperfusion Injury

    Ferroptosis and endoplasmic reticulum stress (ERS) are common events in the process of myocardial ischemia/reperfusion injury (IRI). The suppression of chromobox7 (CBX7) has been reported to protect against is...

    Weipeng Jiang, Zeyu Yan, Xueou Zheng, Shiyi Huang… in Cell Biochemistry and Biophysics (2024)

  14. No Access

    Article

    Tannic Acid Impedes the Proliferation of Bladder Cancer Cells by Elevating Mitochondrial Pathways of Apoptosis

    Bladder cancer stands as a prevailing neoplasm among men globally, distinguished for its pronounced malignancy attributed to invasiveness and metastatic proclivity. Tannic acid (TA), an organic compound in man...

    Chi-Cheng Li, Bruce Chi-Kang Tsai… in Cell Biochemistry and Biophysics (2024)

  15. No Access

    Article

    Recent Progress in Mesenchymal Stem Cell-Derived Exosomes for Skin Wound Repair

    Background: Exosomes are nanometer-sized, lipid bilayer membrane vesicles that are secreted by various cell types. Mesenchymal stem cells (MSCs) have been shown to exert therapeutic effects through the secreti...

    Peilin **e, **aodong Xue, **aodong Li in Cell Biochemistry and Biophysics (2024)

  16. Article

    Open Access

    Protective Effect of CXCR7 Against Hypoxia/Reoxygenation Injury in Renal Tubular Epithelial Cells

    Acute kidney injury (AKI) is a multifactorial syndrome with complex pathophysiology and prognosis. Ischaemia‒reperfusion injury (IRI) is a major cause of induced AKI. The aim of this study was to investigate t...

    ** Meng, Chunli Liu, **gchun Li, ** Fang… in Cell Biochemistry and Biophysics (2024)

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  17. No Access

    Article

    TRIM47 silencing inhibits the malignant biological behaviors of prostate cancer cells by regulating MDM2/p53 signaling

    Prostate cancer (PCa) is a prevalent male malignancy globally. Tripartite motif 47 (TRIM47) has been reported to be associated with PCa. However, how TRIM47 acts on PCa is still incompletely understood. Here, ...

    Chengyong Wang, Rui Chang, Jian Li, Liqiang Li in Cell Biochemistry and Biophysics (2024)

  18. No Access

    Article

    Inhibitory Effect of Puerarin on Lipopolysaccharide-triggered Inflammatory Responses of Bovine Kidney Cells

    Puerarin (Pue), a flavonoid compound, possesses cytoprotective effects and LPS has been reported to induce renal inflammatory injury in bovine. However, whether Pue inhibits lipopolysaccharide (LPS)-induced in...

    Lingbo Zhou, Shasha Liu, Huizhen Li, Shujun Wu, Yan Cao in Cell Biochemistry and Biophysics (2024)

  19. No Access

    Article

    Lentinan mitigates pemetrexed chemoresistance by the PI3K/Akt pathway in non-small cell lung cancer

    Pemetrexed is a folate analog metabolic inhibitor that is given for therapy of non-small cell lung cancer (NSCLC). Drug resistance affects the efficacy of pemetrexed in NSCLC. Lentinan is a polysaccharide extr...

    ** Tian, Dajun Du, Li Yang, Nan Zhou, Ling Tao in Cell Biochemistry and Biophysics (2024)

  20. No Access

    Article

    Knocking Down PIAS3 Reduces H2O2-induced Oxidative Stress Injury in HT22 Cells

    Oxidative stress is involved in the pathological processes of many neurodegenerative diseases. Protein modification by small ubiquitin-like modifiers (SUMOs) has been implicated in oxidative stress injury. By ...

    Baixue Wang, Wenxin Qian, Kaiyue Chen, Meng Li… in Cell Biochemistry and Biophysics (2024)

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