13,108 Result(s)

Article

Correction: Empaglifozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress

Ronghua Fang, Jie Chen, Jiangchuan Long, Binghan Zhang, Qixuan Huang… in Biogerontology (2024)

Article

Correction to: Knock‑Down of CD24 in Astrocytes Aggravates Oxyhemoglobin‑Induced Hippocampal Neuron Impairment

**ang‑**n Chen, Tao Tao, Sen Gao, Han Wang, **ao‑Ming Zhou… in Neurochemical Research (2024)

Article

Esketamine Prevents Postoperative Emotional and Cognitive Dysfunction by Suppressing Microglial M1 Polarization and Regulating the BDNF-TrkB Pathway in Ageing Rats with Preoperative Sleep Disturbance

Postoperative depression (POD) and postoperative cognitive dysfunction (POCD) have placed heavy burden on patients’ physical and mental health in recent years. Sleep disturbance before surgery is a common phen...

Yuxin Wen, Jiawen Xu, Jiahong Shen, Zili Tang, Shuxin Li… in Molecular Neurobiology (2024)

Article

The Association Between Branched-Chain Amino Acid Concentrations and the Risk of Autism Spectrum Disorder in Preschool-Aged Children

Several studies have linked branched-chain amino acid (BCAA) metabolism disorders with autism spectrum disorder (ASD), but the results have been inconsistent. The purpose of this study was to explore the assoc...

Qi Gao, Dan Bi, Bingbing Li, Min Ni, Dizhou Pang, **an Li… in Molecular Neurobiology (2024)

Article

GDPD3 Deficiency Alleviates Neuropathic Pain and Reprograms Macrophagic Polarization Through PGE2 and PPARγ Pathway

The complex mechanism of neuropathic pain involves various aspects of both central and peripheral pain conduction pathways. An effective cure for neuropathic pain therefore remains elusive. We found that defic...

Wenqian Li, Youjia Fan, Haizhen Lan, **aoxiao Li, Qichao Wu… in Neurochemical Research (2024)

Article

HCMV IE1/IE1mut Therapeutic Vaccine Induces Tumor Regression via Intratumoral Tertiary Lymphoid Structure Formation and Peripheral Immunity Activation in Glioblastoma Multiforme

Glioblastoma multiforme (GBM), a highly malignant invasive brain tumor, is associated with poor prognosis and survival and lacks an effective cure. High expression of the human cytomegalovirus (HCMV) immediate...

**aoli Yang, Shasha Jiang, Fengjun Liu, Zonghui Li, Wenxuan Liu… in Molecular Neurobiology (2024)

Article

DNA methylation age acceleration contributes to the development and prediction of non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is prevalent in the aging society. Despite body weight reduction, the prevalence of NAFLD has been increasing with aging for unknown reasons. Here, we investigate the ...

Mingfeng **a, Wenran Li, Huandong Lin, Hailuan Zeng, Shuai Ma, Qi Wu, Hui Ma… in GeroScience (2024)

Article

MiR-425-5p suppression of Crebzf regulates oocyte aging via chromatin modification

Female infertility due to declining oocyte quality with age remains a significant challenge for patients and physicians, despite extensive research efforts. Recent studies suggest that microRNAs (miRNAs), whic...

Kadiliya Jueraitetibaike, Ting Tang, Rujun Ma, Shanmeizi Zhao, Ronghua Wu… in GeroScience (2024)

Article

Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity

Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disease, and approximately 10% of AD cases are early-onset familial AD (EOFAD), which is mainly linked to point mutations in genes encod...

Chenhao Gao, Junkui Shang, Zhengyu Sun, Mingrong **a, Dandan Gao… in Molecular Neurobiology (2024)

Article

Integrated transcriptomics and metabolomics provide insights into the biosynthesis of militarine in the cell suspension culture system of Bletilla striata

Militarine is a monomer molecule with abundant and distinctive biological properties, also the lead member of secondary metabolites in Bletilla striata, while its biosynthesis mechanism is still unknown. To impro...

Qingqing Li, Mengwei Xu, Fengju Wu, Ziyi Guo, Ning Yang, Lin Li… in Advanced Biotechnology (2024)

Article

Correction: Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis

Xue Li, Yulin Chen, Ran Lu, Min Hu, Lei Gu, Qiaorong Huang, Wentong Meng… in Oncogene (2024)

Article

Correction: HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA

Tingting **, Ziming Wang, Fan Fan, Wandi Wei, Chenming Zhou… in Neurochemical Research (2024)

Article

Editorial Expression of Concern: Deacetylation of cortactin by SIRT1 promotes cell migration

Y. Zhang, M. Zhang, H. Dong, S. Yong, X. Li, N. Olashaw, P. A. Kruk… in Oncogene (2024)

Article

SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study

A dose-escalation and expansion, phase 1/2 study (ClinicalTrials.gov, NCT04818333) was conducted to assess the novel antibody-drug conjugate SHR-A1811 in pretreated HER2-altered advanced non-small cell lung ca...

Ziming Li, Zhengbo Song, Wei Hong, Nong Yang… in Signal Transduction and Targeted Therapy (2024)

Article

SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients

Cuprotosis related genes (CRGs) have been proved to be potential therapeutic targets for coronavirus disease 2019 (COVID-19) and cancer, but their immune and molecular mechanisms in COVID-19 infection in Diffu...

Can Chen, Yun Li, Yiwei Li, Zhenzhen Chen, Pengfei Shi, … in Apoptosis (2024)

Article

ESF1 and MIPEP proteins promote estrogen receptor-positive breast cancer proliferation and are associated with patient prognosis

Estrogen receptor-positive (ER+) breast cancer accounts for two-thirds of all breast cancers, and its early and late recurrences still threaten patients’ long-term survival and quality of life. Finding candida...

Qing Yu, Chunhua Qu, **liang Liang, Peiqi Chen, Kaiying Zhang… in Clinical Proteomics (2024)

Article

FADD regulates adipose inflammation, adipogenesis, and adipocyte survival

Adipose tissue, aside from adipocytes, comprises various abundant immune cells. The accumulation of low-grade chronic inflammation in adipose tissue serves as a primary cause and hallmark of insulin resistance...

Jianlei Tang, Yue Ma, Meilin Li, **angpeng Liu, Yuting Wang… in Cell Death Discovery (2024)

Article

Dihydroorotase MoPyr4 is required for development, pathogenicity, and autophagy in rice blast fungus

Dihydroorotase (DHOase) is the third enzyme in the six enzymatic reaction steps of the endogenous pyrimidine nucleotide de novo biosynthesis pathway, which is a metabolic pathway conserved in both bacteria and...

**g-Yi Wang, Ying-Ying Cai, Lin Li, Xue-Ming Zhu… in Cell Communication and Signaling (2024)

Article

Targeting oncogene-induced cellular plasticity for tumor therapy

Cellular plasticity, the remarkable adaptability of cancer cells to survive under various stress conditions, is a fundamental hallmark that significantly contributes to treatment resistance, tumor metastasis, ...

Bin Li, Lingling Zheng, Jianhua Yang, Lianghu Qu in Advanced Biotechnology (2024)

Article

HMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage

Drug-induced organic damage encompasses various intricate mechanisms, wherein HMGB1, a non-histone chromosome-binding protein, assumes a significant role as a pivotal hub gene. The regulatory functions of HMGB...

JianYe Yuan, Lin Guo, JiaTing Ma, HeJian Zhang… in Cell Biology and Toxicology (2024)