478 Result(s)

Article

Correction to: Gonadal mosaicism mediated female-biased gender control in mice

Meizhu Bai, Dan Liang, Yan Cheng, Guolong Liu, Qiudao Wang, **song Li… in Protein & Cell (2022)

Article

Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries, however, the underlying mechanism, in particular immune responses in different organs, remains elusive. In th...

Chun-Chun Gao, Man Li, Wei Deng, Chun-Hui Ma, Yu-Sheng Chen… in Protein & Cell (2022)

Article

Efficient expansion of rare human circulating hematopoietic stem/progenitor cells in steady-state blood using a polypeptide-forming 3D culture

Although widely applied in treating hematopoietic malignancies, transplantation of hematopoietic stem/progenitor cells (HSPCs) is impeded by HSPC shortage. Whether circulating HSPCs (cHSPCs) in steady-state bl...

Yulin Xu, **angjun Zeng, Mingming Zhang, Binsheng Wang, **n Guo, Wei Shan… in Protein & Cell (2022)

Article

Postnatal state transition of cardiomyocyte as a primary step in heart maturation

Postnatal heart maturation is the basis of normal cardiac function and provides critical insights into heart repair and regenerative medicine. While static snapshots of the maturing heart have provided much in...

Zheng Li, Fang Yao, Peng Yu, Dandan Li, Mingzhi Zhang, Lin Mao… in Protein & Cell (2022)

Article

Tsai Chiao: The founder of physiology and aviation, aerospace and navigation medicine in China

Yalan Wang, Zijian Li, Yanyan Qian, Benyu Guo in Protein & Cell (2022)

Article

Gonadal mosaicism mediated female-biased gender control in mice

Meizhu Bai, Dan Liang, Yan Cheng, Guolong Liu, Qiudao Wang, **song Li… in Protein & Cell (2022)

Article

Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

In the original publication the author’s name ‘Dimitri Lavillete’ is published incorrectly. The correct author name should be spelt as ‘Dimitri Lavillette’ is provided in this correction.

Rui **ong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang… in Protein & Cell (2022)

Article

New pathogenic insights from large animal models of neurodegenerative diseases

Animal models are essential for investigating the pathogenesis and develo** the treatment of human diseases. Identification of genetic mutations responsible for neurodegenerative diseases has enabled the cre...

Peng Yin, Shihua Li, **ao-Jiang Li, Weili Yang in Protein & Cell (2022)

Article

Darwinian rebel: The legacy of Loh-Seng Tsai—Chinese animal psychologist

Yong Wang, Wei Chen, Shiying Li, Bin Yin in Protein & Cell (2022)

Article

Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis

Li Yang, ** Chen, Jianqing Liang, Yufeng Zhang, Qingzhe Wang… in Protein & Cell (2022)

Article

An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope

New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design. Here, we identified a re...

Zezhong Liu, Wei Xu, Zhenguo Chen, Wangjun Fu, Wuqiang Zhan, Yidan Gao… in Protein & Cell (2022)

Article

SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation

The nucleocapsid (N) protein of SARS-CoV-2 has been reported to have a high ability of liquid-liquid phase separation, which enables its incorporation into stress granules (SGs) of host cells. However, whether...

Yichen Li, Shuaiyao Lu, **ge Gu, Wencheng **a, Shengnan Zhang… in Protein & Cell (2022)

Article

Hyperthermia differentially affects specific human stem cells and their differentiated derivatives

Si Wang, Fang Cheng, Qianzhao Ji, Moshi Song, Zeming Wu, Yiyuan Zhang… in Protein & Cell (2022)

Article

Legacy of Hongxi Su: Pioneer of Chinese Cardiosurgery

Sumin Yang, Haoyu Hu, **n Zheng, Shizhong Wang, Li Yuan in Protein & Cell (2022)

Article

BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding

Chemically defined medium is widely used for culturing mouse embryonic stem cells (mESCs), in which N2B27 works as a substitution for serum, and GSK3β and MEK inhibitors (2i) help to promote ground-state pluri...

Mingzhu Wang, Kun Zhao, Meng Liu, Mengting Wang, Zhibin Qiao, Shanru Yi… in Protein & Cell (2022)

Article

LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells

LIN28 is an RNA binding protein with important roles in early embryo development, stem cell differentiation/reprogramming, tumorigenesis and metabolism. Previous studies have focused mainly on its role in the ...

Zhen Sun, Hua Yu, **g Zhao, Tianyu Tan, Hongru Pan, Yuqing Zhu… in Protein & Cell (2022)

Article

Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda

The fall armyworm (FAW), Spodoptera frugiperda, is a destructive pest native to America and has recently become an invasive insect pest in China. Because of its rapid spread and great risks in China, understandin...

Furong Gui, Tianming Lan, Yue Zhao, Wei Guo, Yang Dong, Dongming Fang… in Protein & Cell (2022)

Article

Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice

Aging-induced changes in the immune system are associated with a higher incidence of infection and vaccination failure. Lymph nodes, which filter the lymph to identify and fight infections, play a central role...

He Li, Lei Zhu, Rong Wang, Lihui **e, Jie Ren, Shuai Ma, Weiqi Zhang… in Protein & Cell (2022)

Article

Low-dose chloroquine treatment extends the lifespan of aged rats

Wei Li, Zhiran Zou, Yusheng Cai, Kuan Yang, Si Wang, Zunpeng Liu… in Protein & Cell (2022)

Article

Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies

Hu Dong, Pan Liu, Manyuan Bai, Kang Wang, Rui Feng, Dandan Zhu, Yao Sun… in Protein & Cell (2022)