4 Result(s)
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Article
Longzhi Tan
English
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Article
Open AccessSimultaneous single-cell three-dimensional genome and gene expression profiling uncovers dynamic enhancer connectivity underlying olfactory receptor choice
The simultaneous measurement of three-dimensional (3D) genome structure and gene expression of individual cells is critical for understanding a genome’s structure–function relationship, yet this is challenging...
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Article
Open AccessCardiogenic control of affective behavioural state
Emotional states influence bodily physiology, as exemplified in the top-down process by which anxiety causes faster beating of the heart1–3. However, whether an increased heart rate might itself induce anxiety or...
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Article
Open AccessCoordination of two enhancers drives expression of olfactory trace amine-associated receptors
Olfactory sensory neurons (OSNs) are functionally defined by their expression of a unique odorant receptor (OR). Mechanisms underlying singular OR expression are well studied, and involve a massive cross-chrom...
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Article
Three-dimensional genome structures of single sensory neurons in mouse visual and olfactory systems
Sensory neurons in the mouse eye and nose have unusual chromatin organization. Here we report their three-dimensional (3D) genome structure at 20-kilobase (kb) resolution, achieved by applying our recently dev...
