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  1. Article

    Enalapril inhibits tubulointerstitial inflammation and NLRP3 inflammasome expression in BSA-overload nephropathy of rats

    Proteinuria is not only a common marker of renal disease, but also involved in renal tubulointerstitial inflammation and fibrosis. The aim of this study was to investigate the mechanisms underlying the protect...

    Li-hong Ding, Dan Liu, Min Xu, Hong Liu, Min Wu, Ri-ning Tang… in Acta Pharmacologica Sinica (2014)

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  2. Article

    FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway

    FTY720, a new immunomodulatory drug with low cytotoxicity, is currently used to treat multiple sclerosis. In this study, we investigated the effects of FTY720 on inflammatory cell infiltration in albumin overl...

    Min Xu, Dan Liu, Li-hong Ding, Kun-ling Ma, Min Wu, Lin-li Lv… in Acta Pharmacologica Sinica (2014)

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  3. Article

    Involvement of endoplasmic reticulum stress in angiotensin II-induced NLRP3 inflammasome activation in human renal proximal tubular cells in vitro

    NLRP3 inflammasome plays an important role in renal injury and may be a therapeutic target in the treatment of patients with progressive chronic kidney disease. In this study we investigated whether angiotensi...

    **g Wang, Yi Wen, Lin-li Lv, Hong Liu, Ri-ning Tang… in Acta Pharmacologica Sinica (2015)

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  4. Article

    CCN3 suppresses TGF-β1-induced extracellular matrix accumulation in human mesangial cells in vitro

    Glomerular sclerosis is characterized by mesangial cell proliferation and progressive extracellular matrix (ECM) accumulation. CCN3 belongs to the CCN family of matrix proteins; increasing evidence suggests th...

    Hai-fei Liu, Hong Liu, Lin-li Lv, Kun-ling Ma, Yi Wen… in Acta Pharmacologica Sinica (2018)

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    Article

    FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling

    Incomplete recovery from episodes of acute kidney injury (AKI) can predispose patients to develop chronic kidney disease (CKD). Although hypoxia-inducible factor-1α (HIF-1α) is a master regulator of the respon...

    Zuo-lin Li, Bin Wang, Lin-li Lv, Tao-tao Tang, Yi Wen… in Acta Pharmacologica Sinica (2021)

  6. No Access

    Article

    Quercetin alleviates tubulointerstitial inflammation by inhibiting exosomes-mediated crosstalk between tubular epithelial cells and macrophages

    Tubulointerstitial inflammation (TII) is a critical pathological feature of kidney disease leading to renal fibrosis, and its treatment remains a major clinical challenge. We sought to explore the role of quer...

    Di Yin, **g-Yuan Cao, Yan Yang, Zhong-Tang Li, Hong Liu… in Inflammation Research (2023)