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  1. No Access

    Article

    Isolation and characterization of conserved non-coding sequences among rice (Oryza sativa L.) paralogous regions

    Segmental duplication is particularly frequent within plant genomes and the ability of the original single-copy gene to gain a new function for the change of regulatory elements is one of the prominent consequ...

    **anran Li, Lubin Tan, Liguo Wang, Songnian Hu… in Molecular Genetics and Genomics (2009)

  2. No Access

    Article

    Differential gene expression and associated QTL map** for cotton yield based on a cDNA-AFLP transcriptome map in an immortalized F2

    cDNA-AFLP techniques have found new applications in recent years. Currently, the methodology is used to establish differential gene expression and construct linkage maps. In the present study, a transcriptome ...

    Renzhong Liu, Baohua Wang, Wangzhen Guo, Liguo Wang… in Theoretical and Applied Genetics (2011)

  3. No Access

    Article

    Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

    LRP5/6 is a Wnt co-receptor essential for Wnt/β-catenin signaling. X-ray crystallography and electron microscopy analyses now reveal that the LRP6 extracellular ligand-binding domain is composed of two pairs o...

    Zhihong Cheng, Travis Biechele, Zhiyi Wei… in Nature Structural & Molecular Biology (2011)

  4. No Access

    Article

    Controlled Endolysosomal Release of Agents by pH-responsive Polymer Blend Particles

    A key step of delivering extracellular agents to its intracellular target is to escape from endosomal/lysosomal compartments, while minimizing the release of digestive enzymes that may compromise cellular func...

    ** Zhan, Kenny K. Tran, Liguo Wang, Hong Shen in Pharmaceutical Research (2015)

  5. No Access

    Article

    PpV, acting via the JNK pathway, represses apoptosis during normal development of Drosophila wing

    Apoptosis is one of the main fundamental biological processes required for development of multicellular organisms. Inappropriate regulation of apoptosis can lead to severe developmental abnormalities and disea...

    Chunli Chi, Liguo Wang, Wenwen Lan, Long Zhao, Ying Su in Apoptosis (2018)

  6. No Access

    Article

    Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy

    The discovery of effective therapeutic treatments for cancer via cell differentiation instead of antiproliferation remains a great challenge. Cyclin-dependent kinase 2 (CDK2) inactivation, which overcomes the ...

    Liguo Wang, Xue**g Shao, Tianbai Zhong, Yue Wu, Aixiao Xu… in Nature Chemical Biology (2021)