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  1. Article

    Open Access

    Extensive intratumor regional epigenetic heterogeneity in clear cell renal cell carcinoma targets kidney enhancers and is associated with poor outcome

    Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mut...

    Louis Y. El Khoury, **aoyu Pan, Ryan A. Hlady, Ryan T. Wagner… in Clinical Epigenetics (2023)

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  2. Article

    Open Access

    Identification of DNA methylation signatures associated with poor outcome in lower-risk Stage, Size, Grade and Necrosis (SSIGN) score clear cell renal cell cancer

    Despite using prognostic algorithms and standard surveillance guidelines, 17% of patients initially diagnosed with low risk clear cell renal cell carcinoma (ccRCC) ultimately relapse and die of recurrent disea...

    Louis Y. El Khoury, Shuang Fu, Ryan A. Hlady, Ryan T. Wagner… in Clinical Epigenetics (2021)

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