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  1. Article

    Open Access

    Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

    Anillin (ANLN) is a mitosis-related protein that promotes contractile ring formation and cytokinesis, but its cell cycle-dependent degradation mechanisms in cancer cells remain unclear. Here, we show that high...

    Yu-Fei Cao, Lei **e, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi… in Cell Death & Differentiation (2023)

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  2. No Access

    Article

    The post-translational modification of Fascin: impact on cell biology and its associations with inhibiting tumor metastasis

    The post-translational modifications (PTMs), which are crucial in the regulation of protein functions, have great potential as biomarkers of cancer status. Fascin (Fascin actin-bundling protein 1, FSCN1), a key p...

    Nan-Li, Zhi-Da Zhang, Rong-Rong Li, Jia-You Chen, Hong-**n Huang… in Amino Acids (2022)

  3. Article

    Open Access

    Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma

    Esophageal squamous cell carcinoma (ESCC) is one of the world’s leading causes of death, and its primary clinical therapy relies on surgical resection, chemotherapy, radiotherapy, and chemoradiotherapy. Althou...

    Zhen-Yuan Zheng, Man-Yu Chu, Wan Lin, Ya-Qi Zheng, **u-E Xu… in Cell Death & Disease (2022)

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  4. No Access

    Article

    Promotion of rs3746804 (p. L267P) polymorphism to intracellular SLC52A3a trafficking and riboflavin transportation in esophageal cancer cells

    Riboflavin is an essential micronutrient for normal cellular growth and function. Lack of dietary riboflavin is associated with an increased risk for esophageal squamous cell carcinoma (ESCC). Previous studies...

    Lin Long, **ao-**ao Pang, Fa-Min Zeng, **u-Hui Zhan, Ying-Hua **e, Feng Pan… in Amino Acids (2021)

  5. Article

    Open Access

    SLC52A3 expression is activated by NF-κB p65/Rel-B and serves as a prognostic biomarker in esophageal cancer

    The human riboflavin transporter-3 (encoded by SLC52A3) plays a prominent role in riboflavin absorption. Interestingly, abnormal expression patterns of SLC52A3 in multiple types of human cancers have been recentl...

    Lin Long, **ao-**ao Pang, Fei Lei, Jia-Sheng Zhang… in Cellular and Molecular Life Sciences (2018)

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  6. No Access

    Article

    Fascin phosphorylation sites combine to regulate esophageal squamous cancer cell behavior

    Filopodia are dynamic membrane extensions generated by F-actin bundling and are involved in cancer cell migration, invasion and metastasis. Fascin is the crucial actin-bundling protein in filopodia, with phosp...

    Fa-Min Zeng, **ao-Ning Wang, Hong-Shun Shi, Jian-Jun **e, Ze-Peng Du… in Amino Acids (2017)

  7. No Access

    Article

    Specificity protein 1 regulates fascin expression in esophageal squamous cell carcinoma as the result of the epidermal growth factor/extracellular signal-regulated kinase signaling pathway activation

    The overexpression of fascin in human carcinomas is associated with aggressive clinical phenotypes and poor prognosis. However, the molecular mechanism underlying the increased expression of fascin in cancer c...

    **ao-Feng Lu, En-Min Li, Ze-Peng Du, Jian-Jun **e… in Cellular and Molecular Life Sciences (2010)