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Three isoforms of annexin I are preferentially expressed in normal esophageal epithelia but down-regulated in esophageal squamous cell carcinomas
The development and progression of human cancer are believed to be due to the alterations of multiple genes or/and their protein products. For identifying the proteins associated with esophageal cancer, we ana...
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Article
Disruption of the Rad9/Rad1/Hus1 (9–1–1) complex leads to checkpoint signaling and replication defects
The checkpoint sliding-clamp complex, Rad9/Rad1/Hus1, plays a critical role during initiation of checkpoint signals in response to DNA damage and replication disruption. We investigated the impact of loss of R...
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Article
ERβ exerts multiple stimulative effects on human breast carcinoma cells
Recent studies of ERs in breast cancer have demonstrated the existence of ERβ in addition to ERα. Some clinical data indicated that ERβ had prognostic value for patient's survival, which suggested that ERβ plays ...
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Article
Proteomic analysis on metastasis-associated proteins of human hepatocellular carcinoma tissues
Purpose: A comparative proteomic approach was used to identify and analyze proteins related to metastasis of hepatocellular carcinoma (HCC). Methods: Proteins extracted from 12 HCC tissue...
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Article
Limitation of the Augmentation Index for Evaluating Arterial Stiffness
Although the augmentation index (AIx) is widely used to evaluate arterial stiffness in clinics and research, some conflicting data exist in regard to its validity. We therefore performed a series of studies to...
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Article
Paraneoplastic syndromes of hypercalcemia and leukocytosis associated with colonic metastases from squamous cell carcinoma of the lung
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Article
The Study of Aortic Stiffness in Different Hypertension Subtypes in Dialysis Patients
The aim of this study was to validate whether differences in aortic stiffness are responsible for the differences in cardiovascular mortality among hypertension subtypes. Twenty hundred and fifty continuous am...
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Article
Expression of fascin in thyroid neoplasms: a novel diagnostic marker
Fascin, an actin-bundling protein, is markedly upregulated in several epithelial tumors and its expression often correlates with high-grade, extensive invasion, and distant metastasis. However, reports about f...
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Article
Identification of a novel GNAS mutation for pseudohypoparathyroidism in a Chinese family
Pseudohypoparathyroidism (PHP) is a heterogeneous group of diseases characterized by hormone resistance to receptors that stimulate adenylate cyclase. PHP-Ia patients show specific Gs-alpha protein deficiency,...
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Article
The angiogenic and prognostic implications of VEGF, Ang-1, Ang-2, and MMP-9 for hepatocellular carcinoma with background of hepatitis B virus
The objective of this study was to investigate the expressions of angiogenic factors and elucidate their angiogenic and prognostic roles in hepatocellular carcinoma (HCC) with background of hepatitis B virus (...
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Article
Open AccessPleural fluid soluble triggering receptor expressed on myeloid cells-1 as a marker of bacterial infection: a meta-analysis
Pleural infection is a common clinical problem. Its successful treatment depends on rapid diagnosis and early initiation of antibiotics. The measurement of soluble triggering receptor expressed in myeloid cell...
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Article
Polymorphism of vascular endothelial growth factor –2578C/A with cancer risk: evidence from 11263 subjects
Published data on the association between vascular endothelial growth factor (VEGF) –2578C/A polymorphism and cancer risk is inconclusive. To derive a more precise estimation of association between VEGF –2578C...
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Article
Open AccessIn vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundice
Responsiveness of the "jaundiced heart" to propofol is not completely understood. The purpose of this study was to evaluate the effect of propofol on myocardial performance in rats with obstructive jaundice.
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Article
Open AccessVisceral larva migrans associated with earthworm and gecko ingestion: a case report
Visceral larva migrans is a syndrome caused by an infection with larval helminths, which may result in partial or general pathological changes in host tissues. Due to the difficulty in finding the causative pa...
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Article
Experiment on the feasibility of using modified gelatin nanoparticles as insulin pulmonary administration system for diabetes therapy
Polymeric nanoparticles are widely used as targeted carriers for biomacromolecules. In this paper, modified gelatin nanoparticles were prepared and their feasibility as insulin pulmonary administration system ...
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Article
TP53 mutation is not an independent prognostic factor in patients with mantle cell lymphoma at advanced stage
Mantle cell lymphoma (MCL) is incurable in most patients. Several molecular markers have been identified as possible prognostic factors in MCL, including TP53 mutations. Direct sequencing was used to detect 32...
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Article
Open AccessPrimary intestinal lymphangiectasia diagnosed by double-balloon enteroscopy and treated by medium-chain triglycerides: a case report
Primary intestinal lymphangiectasia is a disorder characterized by exudative enteropathy resulting from morphologic abnormalities of the intestinal lymphatics. Intestinal lymphangiectasia can be primary or sec...
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Article
The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women
To investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and ...
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Article
Open AccessProgressive balloon dilatation following hepaticojejunostomy improves outcome of bile duct stricture after iatrogenic biliary injury
Iatrogenic biliary stricture (IBS) is a disastrous complication of cholecystectomy. Although the endoscopic treatments are well accepted as initial attempts for IBS, surgical hepaticojejunostomy (HJ) is often ...
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Article
Open AccessProteomic analysis of extremely severe hand, foot and mouth disease infected by enterovirus 71
To clarify the molecular mechanisms that participate in the severe hand, foot and mouth disease (HFMD) infected by Enterovirus 71 and to detect any related protein biomarkers, we performed proteomic analysis o...