19 Result(s)

Article

Disease-induced changes in bacterial and fungal communities from plant below- and aboveground compartments

The plant microbes are an integral part of the host and play fundamental roles in plant growth and health. There is evidence indicating that plants have the ability to attract beneficial microorganisms through...

Mingfeng Cao, Songqing Huang, **g**g Li… in Applied Microbiology and Biotechnology (2024)

Article

The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights

Skeletal muscle is the largest metabolic organ of the human body. Maintaining the best quality control and functional integrity of mitochondria is essential for the health of skeletal muscle. However, mitochon...

Yuhang Lei, Mailin Gan, Yanhao Qiu, Qiuyang Chen… in Cellular & Molecular Biology Letters (2024)

Article

Improving the production of carbamoyltobramycin by an industrial Streptoalloteichus tenebrarius through metabolic engineering

Tobramycin is an essential and extensively used broad-spectrum aminoglycoside antibiotic obtained through alkaline hydrolysis of carbamoyltobramycin, one of the fermentation products of Streptoalloteichus tenebra...

Yun Feng, Yiqi Jiang, Xutong Chen, Li Zhu… in Applied Microbiology and Biotechnology (2024)

Article

The application of phenylboronic acid pinacol ester functionalized ROS-responsive multifunctional nanoparticles in the treatment of Periodontitis

Periodontitis is an inflammatory disease induced by the complex interactions between the host immune system and the microbiota of dental plaque. Oxidative stress and the inflammatory microenvironment resulting...

**hong Chen, Aihua Luo, Mengmeng Xu, Yao Zhang, Zheng Wang… in Journal of Nanobiotechnology (2024)

Article

Macrophage membrane-camouflaged pH-sensitive nanoparticles for targeted therapy of oral squamous cell carcinoma

Oral cancer is the most common malignant tumor of the head and neck, and 90% of cases are oral squamous cell carcinoma (OSCC). Chemotherapy is an important component of comprehensive treatment for OSCC. Howeve...

Lin Yang, Hongjiao Li, Aihua Luo, Yao Zhang, Hong Chen… in Journal of Nanobiotechnology (2024)

Article

Optimization of welan gum extraction and purification using lysozyme and alkaline protease

Welan gum, a natural polysaccharide produced by Sphingomonas sp. ATCC 31555, has attracted considerable attention in the scientific community due to its desirable properties. However, challenges, such as high vis...

Yuying Wang, TianTian Zhang, Li Zhu, Ruotong Li… in Applied Microbiology and Biotechnology (2024)

Article

miRNAs derived from cobra venom exosomes contribute to the cobra envenomation

Currently, there is an increasing amount of evidence indicating that exosomes and the miRNAs they contain are crucial players in various biological processes. However, the role of exosomes and miRNAs in snake ...

Tianci Liao, Mailin Gan, Yanhao Qiu, Yuhang Lei… in Journal of Nanobiotechnology (2023)

Article

Biomimetic nanoparticles to enhance the reverse cholesterol transport for selectively inhibiting development into foam cell in atherosclerosis

A disorder of cholesterol homeostasis is one of the main initiating factors in the progression of atherosclerosis (AS). Metabolism and removal of excess cholesterol facilitates the prevention of foam cell form...

Li Zhu, Hongjiao Li, Jiyu Li, Yuan Zhong, Shuai Wu… in Journal of Nanobiotechnology (2023)

Article

Preparation of a Klebsiella pneumoniae conjugate nanovaccine using glycol-engineered Escherichia coli

Engineered strains of Escherichia coli have been used to produce bioconjugate vaccines using Protein Glycan Coupling Technology (PGCT). Nanovaccines have also entered the vaccine development arena with advances i...

Yan Liu, Chao Pan, Kangfeng Wang, Yan Guo, YanGe Sun, **ang Li… in Microbial Cell Factories (2023)

Article

Cooked pork-derived exosome nanovesicles mediate metabolic disorder—microRNA could be the culprit

In this study, exosomes from cooked meat were extracted by ultra-high-speed centrifugation. Approximately 80% of exosome vesicles were within 20–200 nm. In addition, the surface biomarkers of isolated exosomes...

Linyuan Shen, Jianfeng Ma, Yiting Yang, Tianci Liao… in Journal of Nanobiotechnology (2023)

Article

Exosomal circ_0026611 contributes to lymphangiogenesis by reducing PROX1 acetylation and ubiquitination in human lymphatic endothelial cells (HLECs)

Esophageal squamous carcinoma (ESCC) is a common malignancy that originates in the digestive tract. Lymph node metastasis (LNM) is a complicated process, and tumor lymphangiogenesis has been reported to be ass...

Wenjian Yao, **angbo Jia, Li Zhu, Lei Xu… in Cellular & Molecular Biology Letters (2023)

Article

Small extracellular vesicles derived from dermal fibroblasts promote fibroblast activity and skin development through carrying miR-218 and ITGBL1

Skin thickness is closely related to the appearance of human skin, such as sagging and wrinkling, which primarily depends on the level of collagen I synthesized by dermal fibroblasts (DFs). Small extracellular...

Qin Zou, Mei Zhang, Rong Yuan, Yifei Wang, Zhengyin Gong… in Journal of Nanobiotechnology (2022)

Article

Orthogonal modular biosynthesis of nanoscale conjugate vaccines for vaccination against infection

Conjugate vaccines represent one of the most effective means for controlling the occurrence of bacterial diseases. Although nanotechnology has been greatly applied in the field of vaccines, it is seldom used f...

**n Li, Chao Pan, Peng Sun, Zhehui Peng, Erling Feng, Jun Wu… in Nano Research (2022)

Article

A novel targeted co-delivery nanosystem for enhanced ovarian cancer treatment via multidrug resistance reversion and mTOR-mediated signaling pathway

Multidrug resistance (MDR) is the main challenge of successful chemotherapy for ovarian cancer patients, with 50% to 75% of ovarian cancer patients eventually relapsed due to it. One of the effective strategie...

Xueqin Wang, Tiandi **ong, Miao Cui, Na Li, Qin Li, Li Zhu… in Journal of Nanobiotechnology (2021)

Article

Hepatic small extracellular vesicles promote microvascular endothelial hyperpermeability during NAFLD via novel-miRNA-7

A recent study has reported that patients with nonalcoholic fatty liver disease (NAFLD) are more susceptible to coronary microvascular dysfunction (CMD), which may predict major adverse cardiac events. However...

Rui Zuo, Li-Feng Ye, Yi Huang, Zi-Qing Song, Lei Wang… in Journal of Nanobiotechnology (2021)

Article

Protective effects of sodium butyrate on rotavirus inducing endoplasmic reticulum stress-mediated apoptosis via PERK-eIF2α signaling pathway in IPEC-J2 cells

Rotavirus (RV) is a major pathogen that causes severe gastroenteritis in infants and young animals. Endoplasmic reticulum (ER) stress and subsequent apoptosis play pivotal role in virus infection. However, the...

Ye Zhao, Ningming Hu, Qin Jiang, Li Zhu… in Journal of Animal Science and Biotechnology (2021)

Article

Manipulating the position of DNA expression cassettes using location tags fused to dCas9 (Cas9-Lag) to improve metabolic pathway efficiency

Deactivated Cas9 (dCas9) led to significant improvement of CRISPR/Cas9-based techniques because it can be fused with a variety of functional groups to form diverse molecular devices, which can manipulate or mo...

Qianwen **e, Siwei Li, Dongdong Zhao, Lijun Ye, Qingyan Li… in Microbial Cell Factories (2020)

Article

Soft - sensing modeling based on ABC - MLSSVM inversion for marine low - temperature alkaline protease MP fermentation process

Aiming at the characteristics of nonlinear, multi-parameter, strong coupling and difficulty in direct on-line measurement of key biological parameters of marine low-temperature protease fermentation process, a...

Bo Wang, Meifang Yu, **anglin Zhu, Li Zhu in BMC Biotechnology (2020)

Article

Molecular cloning and sequence analysis of the sisomicin biosynthetic gene cluster from Micromonospora inyoensis

Wen-Rong Hong, Mei Ge, Zhi-Hong Zeng, Li Zhu, Min-Yu Luo, Lei Shao… in Biotechnology Letters (2009)