60 Result(s)
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Article
Open AccessRole of T cells in liver metastasis
The liver is a major metastatic site (organ) for gastrointestinal cancers (such as colorectal, gastric, and pancreatic cancers) as well as non-gastrointestinal cancers (such as lung, breast, and melanoma cance...
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Article
Open AccessThe role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights
Skeletal muscle is the largest metabolic organ of the human body. Maintaining the best quality control and functional integrity of mitochondria is essential for the health of skeletal muscle. However, mitochon...
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Article
Open AccessThe chromatin remodeling protein BRG1 regulates HSC-myofibroblast differentiation and liver fibrosis
Excessive fibrogenic response in the liver disrupts normal hepatic anatomy and function heralding such end-stage liver diseases as hepatocellular carcinoma and cirrhosis. Myofibroblasts, derived primarily from...
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Article
Open AccessIntegration of FUNDC1-associated mitochondrial protein import and mitochondrial quality control contributes to TDP-43 degradation
Though TDP-43 protein can be translocated into mitochondria and causes mitochondrial damage in TDP-43 proteinopathy, little is known about how TDP-43 is imported into mitochondria. In addition, whether mitocho...
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Article
Feature hypergraph representation learning on spatial-temporal correlations for EEG emotion recognition
Electroencephalogram(EEG) becomes popular in emotion recognition for its capability of selectively reflecting the real emotional states. Existing graph-based methods have made primary progress in representing ...
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Article
Open AccessCerebral endothelial cell-derived extracellular vesicles regulate microglial polarization and promote autophagy via delivery of miR-672-5p
The interaction between cerebral endothelial cells (CEC) and brain parenchymal cells is critical to maintain neurovascular homeostasis, whereas extracellular vesicles (EVs) are essential to mediate the cell–ce...
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Article
A multi-stage dynamical fusion network for multimodal emotion recognition
In recent years, emotion recognition using physiological signals has become a popular research topic. Physiological signal can reflect the real emotional state for individual which is widely applied to emotion...
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Article
The role of blood flow in vessel remodeling and its regulatory mechanism during developmental angiogenesis
Vessel remodeling is essential for a functional and mature vascular network. According to the difference in endothelial cell (EC) behavior, we classified vessel remodeling into vessel pruning, vessel regressio...
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Article
Open AccessExosomal circ_0026611 contributes to lymphangiogenesis by reducing PROX1 acetylation and ubiquitination in human lymphatic endothelial cells (HLECs)
Esophageal squamous carcinoma (ESCC) is a common malignancy that originates in the digestive tract. Lymph node metastasis (LNM) is a complicated process, and tumor lymphangiogenesis has been reported to be ass...
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Article
Synthesis and antibacterial activity of indole 3-substituted-[1,2,4]triazole derivatives
In this work, a series of novel indole 3-substituted-[1,2,4]triazole derivatives was designed and synthesized, and their structures were characterized by 1H, 13C NMR, high-resolution mass spectrometry, and single...
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Article
Open AccessAttention allocation on mobile app interfaces when human interacts with them
With the popularity of smartphones and the pervasion of mobile apps, people spend more and more time to interact with a diversity of apps on their smartphones, especially for young population. This raises a qu...
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Article
Open AccessEmerging mechanisms of pyroptosis and its therapeutic strategy in cancer
Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely associated with tumour development...
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Article
A novel classification method for EEG-based motor imagery with narrow band spatial filters and deep convolutional neural network
The Common Spatial Pattern (CSP) algorithm is the most widely used method for decoding Electroencephalography (EEG) signals from motor imagery (MI) paradigm. However, due to the inter-subject variability, the ...
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Article
Open AccessSingle-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow
Disturbed blood flow (d-flow) has been known to induce changes of the cells in the arterial wall, increasing the risk of atherosclerosis. However, the heterogeneity of the vascular cell populations under d-flo...
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Article
Fasting Increases Iron Export by Modulating Ferroportin 1 Expression Through the Ghrelin/GHSR1α/MAPK Pathway in the Liver
The liver is contributed to maintaining body iron homeostasis and controlling of body adaptation to fasting. Although previous studies implied a negative relationship between iron and ghrelin in both mice and ...
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Article
Open AccessSemaphorin 7A promotes endothelial to mesenchymal transition through ATF3 mediated TGF-β2/Smad signaling
Endothelial to mesenchymal transition (EndMT) is an important pathological change in many diseases. Semaphorin7A (Sema7A) has been reported to regulate nerve and vessel homeostasis, but its role in EndMT remai...
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Article
Development of β-elemene and Cisplatin Co-Loaded Liposomes for Effective Lung Cancer Therapy and Evaluation in Patient-Derived Tumor Xenografts
β-elemene and cisplatin combined chemotherapy currently is one of the most important settings available for lung cancer therapy in China. However, the clinical outcome is limited by their pharmacokinetic drawb...
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Article
Development of a UHPLC-MS method for inhibitor screening against α-L-1,3-fucosidase
α-L-Fucosidase (AFU) is a promising therapeutic target for the treatment of inflammation, cancer, cystic fibrosis, and fucosidosis. Some of the existing analytical methods for the assessment of AFU activity ar...
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Article
Enhanced N-acetyl-d-neuraminic production from glycerol and N-acetyl-d-glucosamine by metabolically engineered Escherichia coli with a two-stage pH-shift control strategy
Typical N-acetyl-d-neuraminic acid (Neu5Ac) production uses N-acetyl-d-glucosamine (GlcNAc) and excess pyruvate as substrates in the enzymatic or whole-cell biocatalysis process. In a previous study, a Neu5Ac-pro...
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Article
Increased productivity of l-2-aminobutyric acid and total turnover number of NAD+/NADH in a one-pot system through enhanced thermostability of l-threonine deaminase
To strengthen NADH regeneration in the biosynthesis of l-2-aminobutyric acid (l-ABA).
