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  1. Article

    Open Access

    The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights

    Skeletal muscle is the largest metabolic organ of the human body. Maintaining the best quality control and functional integrity of mitochondria is essential for the health of skeletal muscle. However, mitochon...

    Yuhang Lei, Mailin Gan, Yanhao Qiu, Qiuyang Chen… in Cellular & Molecular Biology Letters (2024)

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  2. Article

    Open Access

    Exosomal circ_0026611 contributes to lymphangiogenesis by reducing PROX1 acetylation and ubiquitination in human lymphatic endothelial cells (HLECs)

    Esophageal squamous carcinoma (ESCC) is a common malignancy that originates in the digestive tract. Lymph node metastasis (LNM) is a complicated process, and tumor lymphangiogenesis has been reported to be ass...

    Wenjian Yao, **angbo Jia, Li Zhu, Lei Xu… in Cellular & Molecular Biology Letters (2023)

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  3. No Access

    Article

    Synthesis and antibacterial activity of indole 3-substituted-[1,2,4]triazole derivatives

    In this work, a series of novel indole 3-substituted-[1,2,4]triazole derivatives was designed and synthesized, and their structures were characterized by 1H, 13C NMR, high-resolution mass spectrometry, and single...

    Li Zhu, Si-Yu Tang, Dan-** Chen, Cheng-Peng Li, Li-Hui Shao… in Chemical Papers (2023)

  4. No Access

    Article

    Fasting Increases Iron Export by Modulating Ferroportin 1 Expression Through the Ghrelin/GHSR1α/MAPK Pathway in the Liver

    The liver is contributed to maintaining body iron homeostasis and controlling of body adaptation to fasting. Although previous studies implied a negative relationship between iron and ghrelin in both mice and ...

    Qianqian Luo, Jianan Hu, Guang Yang, … in Biological Trace Element Research (2021)

  5. No Access

    Article

    Enhanced N-acetyl-d-neuraminic production from glycerol and N-acetyl-d-glucosamine by metabolically engineered Escherichia coli with a two-stage pH-shift control strategy

    Typical N-acetyl-d-neuraminic acid (Neu5Ac) production uses N-acetyl-d-glucosamine (GlcNAc) and excess pyruvate as substrates in the enzymatic or whole-cell biocatalysis process. In a previous study, a Neu5Ac-pro...

    De-qiang Zhu, Jian-rong Wu, **ao-bei Zhan… in Journal of Industrial Microbiology & Biote… (2019)

  6. No Access

    Article

    Increased productivity of l-2-aminobutyric acid and total turnover number of NAD+/NADH in a one-pot system through enhanced thermostability of l-threonine deaminase

    To strengthen NADH regeneration in the biosynthesis of l-2-aminobutyric acid (l-ABA).

    Ying Wang, Guo-Si Li, Pei Qiao, Ling Lin, Hai-Long Xue, Li Zhu… in Biotechnology Letters (2018)

  7. No Access

    Article

    Expression profile of long non-coding RNAs during the differentiation of human umbilical cord derived mesenchymal stem cells into cardiomyocyte-like cells

    We aimed to investigate the differentially expressed long non-coding RNAs (lncRNAs) during the differentiation of human umbilical cord derived mesenchymal stem cells (hUCMSCs) into cardiomyocyte-like cells ind...

    Zhong-bao Ruan, Ge-cai Chen, Yin Ren, Li Zhu in Cytotechnology (2018)

  8. No Access

    Article

    Different nitrogen sources change the transcriptome of welan gum-producing strain Sphingomonas sp. ATCC 31555

    To reveal effects of different nitrogen sources on the expressions and functions of genes in Sphingomonas sp. ATCC 31555, it was cultivated in medium containing inorganic nitrogen (IN), organic nitrogen (ON), or ...

    **aopeng Xu, Zuoming Nie, Zhiyong Zheng, Li Zhu, Hongtao Zhang… in Archives of Microbiology (2017)

  9. No Access

    Article

    Production of β-carotene by expressing a heterologous multifunctional carotene synthase in Yarrowia lipolytica

    To obtain functional expression of a heterologous multifunctional carotene synthase containing phytoene synthase, phytoene dehydrogenase, and lycopene β-cyclase activities encoded by carS from Schizochytrium sp. ...

    Shuliang Gao, Yangyang Tong, Li Zhu, Mei Ge, Yu Jiang, Daijie Chen… in Biotechnology Letters (2017)

  10. No Access

    Article

    Phosphoenolpyruvate-supply module in Escherichia coli improves N-acetyl-d-neuraminic acid biocatalysis

    N-Acetyl-d-neuraminic acid (Neu5Ac) is often synthesized from exogenous N-acetylglucosamine (GlcNAc) and excess pyruvate. We have previously constructed a recombinant Escherichia coli ...

    Deqiang Zhu, Jianrong Wu, **aobei Zhan, Li Zhu, Zhiyong Zheng… in Biotechnology Letters (2017)

  11. No Access

    Article

    Inhibitor of p53–p21 pathway induces the differentiation of human umbilical cord derived mesenchymal stem cells into cardiomyogenic cells

    P53 is shown recently to play an important role in the proliferation and differentiation of mesenchymal stem cells. In this study, human umbilical cord derived mesenchymal stem cells (hUCMSCs) were isolated an...

    Zhong-Bao Ruan, Li Zhu, Yi-Gang Yin, Ge-Cai Chen in Cytotechnology (2016)

  12. No Access

    Article

    Multiplex gene editing of the Yarrowia lipolytica genome using the CRISPR-Cas9 system

    Yarrowia lipolytica is categorized as a generally recognized as safe (GRAS) organism and is a heavily documented, unconventional yeast that has been widely incorporated into multiple indu...

    Shuliang Gao, Yangyang Tong, Zhiqiang Wen… in Journal of Industrial Microbiology & Biote… (2016)

  13. No Access

    Article

    Expression and Significance of DLL4-–Notch Signaling Pathway in the Differentiation of Human Umbilical Cord Derived Mesenchymal Stem Cells into Cardiomyocytes Induced by 5-Azacytidine

    hUCMSCs were isolated and purified from the umbilical cords of normal or cesarean term deliveries under sterile conditions. Flow cytometry analysis revealed that CD13, CD29, CD44, CD90, and CD105 were highly e...

    Li Zhu, Zhongbao Ruan, Yigang Yin, Gecai Chen in Cell Biochemistry and Biophysics (2015)

  14. No Access

    Article

    One-step integration of multiple genes into the oleaginous yeast Yarrowia lipolytica

    Yarrowia lipolytica is an unconventional yeast, and is generally recognized as safe (GRAS). It provides a versatile fermentation platform that is used commercially to produce many added-value pro...

    Shuliang Gao, Linna Han, Li Zhu, Mei Ge, Sheng Yang, Yu Jiang… in Biotechnology Letters (2014)

  15. No Access

    Article

    Fine map** of a dominant thermo-sensitive genic male sterility gene (BntsMs) in rapeseed (Brassica napus) with AFLP- and Brassica rapa-derived PCR markers

    A new thermo-sensitive dominant genic male sterility (TSDGMS) line of Brassica napus was found and mapped in this paper. Our result will greatly accelerate t...

    **nhua Zeng, Wenpin Li, Yuhuan Wu, Fang Liu… in Theoretical and Applied Genetics (2014)

  16. No Access

    Article

    Establishment of Caenorhabditis elegans SID-1-Dependent DNA Delivery System in Cultured Silkworm Cells

    The systemic RNA interference defective-1 (SID-1) can transport double-stranded RNA (dsRNA) into cytosol across the cytoplasmic membrane. We report here that ectopic expression of Caenorhabditis elegans SID-1 all...

    Jian Xu, Kaito Yoshimura, Hiroaki Mon, Zhiqing Li, Li Zhu… in Molecular Biotechnology (2014)

  17. No Access

    Article

    Type II thioesterase gene (ECO-orf27) from Amycolatopsis orientalis influences production of the polyketide antibiotic, ECO-0501 (LW01)

    ECO-orf27 associated with the cluster of ECO-0501 (LW01) from Amycolatopsis orientalis is deduced to encode a type II thioesterase. Disruption of ECO-orf27 reduced LW01 production by 95 %. Comple...

    Yang Shen, He Huang, Li Zhu, Minyu Luo, Daijie Chen in Biotechnology Letters (2012)

  18. No Access

    Article

    A Causal Analysis of Intra-Abdominal Hemorrhage After Reduced-Size Liver Transplantation in Rat

    In this study, we analyzed causes of abdominal hemorrhage after reduced-size liver transplantation in rat. Healthy SD rats (weight range of 260–280 g) underwent liver transplantation, the donors were female an...

    Liu **g, Li Li, Ran Jiang-Hua, Zhang Sheng-Ning… in Cell Biochemistry and Biophysics (2011)

  19. No Access

    Article

    Map-based cloning proves qGC-6, a major QTL for gel consistency of japonica/indica cross, responds by Waxy in rice (Oryza sativa L.)

    In this study, one major QTL affecting gel consistency (GC) of japonica/indica cross was identified on chromosome 6 using a DH population. To understand the molecular mechanism that regulates GC in rice grains...

    Yan Su, Yuchun Rao, Shikai Hu, Yaolong Yang, Zhenyu Gao… in Theoretical and Applied Genetics (2011)

  20. Article

    Molecular cloning and sequence analysis of the sisomicin biosynthetic gene cluster from Micromonospora inyoensis

    Wen-Rong Hong, Mei Ge, Zhi-Hong Zeng, Li Zhu, Min-Yu Luo, Lei Shao… in Biotechnology Letters (2009)

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