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  1. No Access

    Article

    Increased productivity of l-2-aminobutyric acid and total turnover number of NAD+/NADH in a one-pot system through enhanced thermostability of l-threonine deaminase

    To strengthen NADH regeneration in the biosynthesis of l-2-aminobutyric acid (l-ABA).

    Ying Wang, Guo-Si Li, Pei Qiao, Ling Lin, Hai-Long Xue, Li Zhu in Biotechnology Letters (2018)

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    Article

    Production of β-carotene by expressing a heterologous multifunctional carotene synthase in Yarrowia lipolytica

    To obtain functional expression of a heterologous multifunctional carotene synthase containing phytoene synthase, phytoene dehydrogenase, and lycopene β-cyclase activities encoded by carS from Schizochytrium sp. ...

    Shuliang Gao, Yangyang Tong, Li Zhu, Mei Ge, Yu Jiang, Daijie Chen in Biotechnology Letters (2017)

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    Article

    Phosphoenolpyruvate-supply module in Escherichia coli improves N-acetyl-d-neuraminic acid biocatalysis

    N-Acetyl-d-neuraminic acid (Neu5Ac) is often synthesized from exogenous N-acetylglucosamine (GlcNAc) and excess pyruvate. We have previously constructed a recombinant Escherichia coli ...

    Deqiang Zhu, Jianrong Wu, **aobei Zhan, Li Zhu, Zhiyong Zheng in Biotechnology Letters (2017)

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    Article

    One-step integration of multiple genes into the oleaginous yeast Yarrowia lipolytica

    Yarrowia lipolytica is an unconventional yeast, and is generally recognized as safe (GRAS). It provides a versatile fermentation platform that is used commercially to produce many added-value pro...

    Shuliang Gao, Linna Han, Li Zhu, Mei Ge, Sheng Yang, Yu Jiang in Biotechnology Letters (2014)

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    Article

    Type II thioesterase gene (ECO-orf27) from Amycolatopsis orientalis influences production of the polyketide antibiotic, ECO-0501 (LW01)

    ECO-orf27 associated with the cluster of ECO-0501 (LW01) from Amycolatopsis orientalis is deduced to encode a type II thioesterase. Disruption of ECO-orf27 reduced LW01 production by 95 %. Comple...

    Yang Shen, He Huang, Li Zhu, Minyu Luo, Daijie Chen in Biotechnology Letters (2012)

  6. Article

    Molecular cloning and sequence analysis of the sisomicin biosynthetic gene cluster from Micromonospora inyoensis

    Wen-Rong Hong, Mei Ge, Zhi-Hong Zeng, Li Zhu, Min-Yu Luo, Lei Shao in Biotechnology Letters (2009)

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    Article

    Molecular cloning and sequence analysis of the sisomicin biosynthetic gene cluster from Micromonospora inyoensis

    Micromonospora inyoensis produces sisomicin (Sm), an aminoglycoside antibiotic. The gene cluster of sisomicin biosynthesis spanning ca. 47 kb consists of 37 ORFs encoding various proteins...

    Wun-Rong Hong, Mei Ge, Zhi-Hong Zeng, Li Zhu, Min-Yu Luo, Lei Shao in Biotechnology Letters (2009)