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Open AccessNicotinamide adenine dinucleotide replenishment rescues colon degeneration in aged mice
Susceptibility of gastrointestinal dysmotility increases with age-associated colonic degeneration. A paucity of remedies reversing colonic degeneration per se hinders the fundamental relief of symptoms. Here we d...
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Article
Open AccessSympathetic transmitters control thermogenic efficacy of brown adipocytes by modulating mitochondrial complex V
Obesity is a worldwide epidemic and results from excessive energy intake or inefficient energy expenditure. It is promising to utilize the thermogenic function of brown adipose tissue for obesity intervention....
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Open AccessHistory and progress of hypotheses and clinical trials for Alzheimer’s disease
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its main pathological features a...
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Open AccessThe effect of selective serotonin reuptake inhibitors on cognitive function in patients with Alzheimer’s disease and vascular dementia: focusing on fluoxetine with long follow-up periods
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Open AccessAuthor Correction: History and progress of hypotheses and clinical trials for Alzheimer’s disease
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessHuman herpesvirus 4 and adaptive immunity in Alzheimer’s disease
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Open AccessBcl-3 promotes Wnt signaling by maintaining the acetylation of β-catenin at lysine 49 in colorectal cancer
Wnt/β-catenin signaling plays a critical role in colorectal cancer (CRC) tumorigenesis and the homeostasis of colorectal cancer stem cells (CSCs), but its molecular mechanism remains unclear. B-cell lymphoma 3...
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Open AccessTemporal profiling of plasma cytokines, chemokines and growth factors from mild, severe and fatal COVID-19 patients
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Open AccessCrystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design
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Open AccessIdentification of a hotspot on PD-L1 for pH-dependent binding by monoclonal antibodies for tumor therapy
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Open AccessIGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas
The insulin-like growth factor 1 receptor (IGF-1R) governs several signaling pathways for cell proliferation, survival, and anti-apoptosis. Thus, targeting IGF-1R appears as a reasonable rationale for tumor tr...
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Open AccessHuman umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial
No effective drug treatments are available for coronavirus disease 2019 (COVID-19). Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage, death, or long...
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Open AccessEpitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications
Drug resistance is a major hurdle in cancer treatment and a key cause of poor prognosis. Epitranscriptomics and epiproteomics are crucial in cell proliferation, migration, invasion, and epithelial–mesenchymal ...
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Open AccessNovel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS
Although stress has been known to increase the susceptibility of pathogen infection, the underlying mechanism remains elusive. In this study, we reported that restraint stress dramatically enhanced the morbidi...
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Open AccessKindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice
In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it is modulated is incompletely understood. Here we report that del...
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Open AccessP21-activated kinase 5 potentiates the chemoresistant phenotype of liver cancer
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Open AccessEffect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial
Treatment of severe Coronavirus Disease 2019 (COVID-19) is challenging. We performed a phase 2 trial to assess the efficacy and safety of human umbilical cord-mesenchymal stem cells (UC-MSCs) to treat severe C...
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Open AccessSRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer
Alternative splicing is a critical process to generate protein diversity. However, whether and how alternative splicing regulates autophagy remains largely elusive. Here we systematically identify the splicing...
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Open AccessHLA-mismatched allogeneic adoptive immune therapy in severely immunosuppressed AIDS patients
Severely immunosuppressed AIDS patients with recurrent opportunistic infections (OIs) represent an unmet medical need even in the era of antiretroviral therapy (ART). Here we report the development of a human ...
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Open AccessSafety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial
Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti-CD147 antibody could suppress the in vitro SAR...