5 Result(s)

Article

Publisher Correction to: Adenosine receptor signalling in Alzheimer’s disease

Phuc N. H. Trinh, Jo-Anne Baltos, Shane D. Hellyer, Lauren T. May… in Purinergic Signalling (2022)

Article

Adenosine receptor signalling in Alzheimer’s disease

Alzheimer’s disease (AD) is the most common dementia in the elderly and its increasing prevalence presents treatment challenges. Despite a better understanding of the disease, the current mainstay of treatment...

Phuc N. H. Trinh, Jo-Anne Baltos, Shane D. Hellyer, Lauren T. May… in Purinergic Signalling (2022)

Article

Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A₁ Receptor

Despite intense interest in designing positive allosteric modulators (PAMs) as selective drugs of the adenosine A₁ receptor (A₁AR), structural binding modes of the receptor PAMs remain unknown. Using the first X-...

Yinglong Miao, Apurba Bhattarai, Anh T. N. Nguyen… in Scientific Reports (2018)

Article

Correspondence: Reply to ‘Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury’

Cheng Xue Qin, Lauren T. May, Patrick M. Sexton, Aaron J. DeBono… in Nature Communications (2018)

Article

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

Effective treatment for managing myocardial infarction (MI) remains an urgent, unmet clinical need. Formyl peptide receptors (FPR) regulate inflammation, a major contributing mechanism to cardiac injury follow...

Cheng Xue Qin, Lauren T. May, Renming Li, Nga Cao, Sarah Rosli… in Nature Communications (2017)