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Open AccessAntibodies elicited by the first non-viral prophylactic cancer vaccine show tumor-specificity and immunotherapeutic potential
MUC1 is a shared tumor antigen expressed on >80% of human cancers. We completed the first prophylactic cancer vaccine clinical trial based on a non-viral antigen, MUC1, in healthy individuals at-risk for colon...
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Proteomics-directed cloning of circulating antiviral human monoclonal antibodies
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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
The innate immune system contributes to the earliest phase of the host defense against foreign organisms and has both soluble and cellular pattern recognition receptors for microbial products. Two important me...